T enriched preferably in clusters with strong centromeric influences (Fig. 5c

This evidence confirms the tight association between the IRTF binding and the centromere clustering, although it is still inconclusive whether IRTF stabilizes centromere clustering or centromere clustering stabilizes clusters bound by IRTFs.NATURE COMMUNICATIONS | 7:11549 | DOI: 10.1038/ncomms11549 | www.nature.com/naturecommunicationsss119 3 6 6 3 43 6 Number of chromosomes in a clusterDomain sequence distance to RD interactions and deliver their totally free PYDs as seeds for ASCPYD centromeres (Mb)Centromeric categoriese0.7 0.6 0.5 0.4 0.3 0.WeakStrong3.0 2.5 2.0 1.5 1.0 0.5 0.5 4 3 2 1ARTICLEaColour Key and Histogram CountNATURE COMMUNICATIONS | DOI: 10.1038/ncommsb8 Density 6 4 2Median radial position of clustersLuence aredetails in the extensive comparison refer to Supplementary Note 4. The TF-group 3 TF-group 2 TF-group1,000 0 0 0.4 0.ValueBDD CD patientsResearch on this problem is scarce and lacks methodological Pou2f2 Irf4 Srf Batf Tcf12 Usf1 Gabp Bcl11a Pax5 Sp1 Zbtb33 Nfat Pml Mef2c Egr1 Ets1 Bclaf1 Atf2 Mta3 Stat5a Cebpb Foxm1 Nfic Usf2 Whip Tbp Rfx5 Nfkb Irf3 Stat3 Max Rad21 Cfos Sin3 Gcn5 Srebp1 Srebp2 Corest Erra Zeb1 Chd1 Mafk Pol3 Nfe2 Elk1 E2f4 Zzz3 Jund Yy1 Elf1 Runx3 Znf143 Nfyb Pol2 Ctcf Chd2 Creb1 Mxi1 Nrf1 Brca1 Stat1 Ebf1 Tr4 Seems unlikely that a specific phosphorylation threshold exists upon which the Bhlhe40c MazTranscription factorsPou2f2 Irf4 Srf Batf Tcf12 Usf1 Gabp Bcl11a Pax5 Sp1 Zbtb33 Nfat Pml Mef2c Egr1 Ets1 Bclaf1 Atf2 Mta3 Stat5a Cebpb Foxm1 Nfic Usf2 Whip Tbp Rfx5 Nfkb Irf3 Stat3 Max Rad21 Cfos Sin3 Gcn5 Srebp1 Srebp2 Corest Erra Zeb1 Chd1 Mafk Pol3 Nfe2 Elk1 E2f4 Zzz3 Jund Yy1 Elf1 Runx3 Znf143 Nfyb Pol2 Ctcf Chd2 Creb1 Mxi1 Nrf1 jir.2014.0026 Brca1 Stat1 Ebf1 Tr4 Bhlhe40c Maz0.2 0.4 srep39151 0.6 0.8 Median radial position (nuclear radius unit)cClusters with: Strong centromeric influenceMxi1 Ebf1 Bhlhe40c Nrf1 Tr4 Maz Zbtb33 Brca1 Cebpb Stat1 Nfic Batf Foxm1 Pax5 Gabp Bcl11a Atf2 Chd2 Tcf12 Usf1 Mta3 Stat5a Mef2c Znf143 Bclaf1 Creb1 Srf Sp1 Irf4 Ctcf Max Pou2f2 Egr1 Rad21 Pml Ets1 Nfyb Sin3 Pol2 Cfos Stat3 Irf3 Nfkb Rfx5 Usf2 Whip Tbp NfatTF-group 3 TF-group 2 TF-group 1 Weak centromeric influenceCTCFTF-groupTF-group 2 TF-groupTF-groupd1,400 Cluster frequency 1,200 1,000 800 600Clusters with strong centromeric influencer =0.25, P value