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001), with expression being more in OSCC (Mann-Whitney U test). In OLP cases when cdk4 and Bosutinib chemical structure p16 expression was correlated, 43 of 60 samples expressed p16 antigens with cdk4 positive nuclei and/or cytoplasm. Statistically a significant positive correlation was seen between cdk4 and p16 expression (P Dabigatran with positive staining). In EOLP group, only cytoplasmic cdk4 is frequently expressed; compared to NOLP and normal mucosa (green invisible has a value ... Table 3 Comparison of number of cells having positive cytoplasmic or nuclear expression of cdk4 and p16 in EOLP and NOLP tissue samples Figure 3 Cdk4 and p16 expression in nucleus and cytoplasm in EOLP, NOLP, normal mucosa and OSCC (mean of % no. of cells stained). In EOLP group, only cytoplasmic cdk4 expression is significantly increased; compared to NOLP and normal mucosa (green invisible has ... DISCUSSION This was the first study to compare the cdk4 and p16 expression between EOLP and NOLP. Study results revealed a significantly high expression of cdk4 and p16 in cytoplasm in OLP compared to normal mucosa, for percentage number of cells stained as well as for number of cases having positive staining. cdk4 nuclear expression was not significantly different between OLP and normal mucosa as nuclear cdk4 was detected in 40% of the normal mucosa samples. These findings were contrary to a previous study where cdk4 showed significantly higher expression in nuclei only, in lesional tissue of OLP [5]. Similarly cdk4 and p16 expression was significantly Alpelisib higher in OSCC in both cytoplasm and nuclei, finding supported by the previous studies [4,10]. In normal mucosa, cdk4 expression seen was confined to the nucleus only, suggesting that although cdk4 being a component of nuclear proteins [9], its positivity registered in the cytoplasm in OLP and OSCC cases was not due to a technical error. A significant positive correlation was seen between cdk4 and p16 expression in OLP (P