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Methods We estimated total costs and ART cost savings for the provision of LLIN and WF to 10%1 of HIV-positive adults (15 years and above) awaiting ART eligibility,2 aware of their HIV status, in Kenya. The ART cost savings were estimated over a lifetime horizon, over the lifetime of HIV-positive individuals. The mean lifetime on ART was assumed to be 33 years when individuals initiated ART at a CD4 count of 350 cells/mm3 [average between a Ugandan estimate (20) and a South African estimate (21)], and it was assumed to be the same for all adults. Our analysis focused on ART cost savings, that Ritipenem is, on how ART costs may be deferred (discounted) in time and bring net financial savings. The costs were discounted using a 3% discount rate consistently with cost-effectiveness guidelines (22, 23). Note that likely small increases in background mortality due to deferral of ART initiation were neglected. The duration of intervention benefit is assumed to be T int=3 years; that is, LLIN and WF are assumed to be effective for 3 years [Vestergaard-Frandsen personal communication; Ref. (24)]. This analysis was performed from the perspective of the healthcare provider. All costs were reported in 2011 US dollars. Data We utilized the findings from the multisite Kenya trial (9). The trial followed two prospective cohorts comprising 589 ART-na?ve HIV-1-positive adults from HIV clinics at two sites in Western Kenya. Individuals Volasertib concentration enrolled in the intervention cohort received a LLIN and a WF. Individuals in the control cohort did not receive a LLIN or a WF. Individuals in the intervention cohort had a mean CD4 count at enrollment of 530 cells/mm3 (IQR: 450�C670) as opposed to 550 cells/mm3 (IQR: 440�C690) in the control cohort. CB-839 cost After 2 years, individuals in the intervention cohort were 27% less likely to reach the endpoint of a CD4 count