The Background Around The Crizotinib Success

The patient was a chronic smoker and used to work as a manual labourer with nearly a 35-year history of unprotected exposure to cement dust. On examination, there was thickening of skin over the hands, face and trunk (figure 1, left panel). Skin examination demonstrated ��salt and pepper dermopathy�� (figure 1 right panel). Figure?1 (Left panel) Clinical photograph depicting tightening of skin of both the hands. (Right panel) Salt and peer dermopathy changes are seen over the anterior chest. CT scan of the thorax demonstrated small calcified mediastinal lymph nodes (figure 2 left panel) and a thin-walled cavity with surrounding nodules in the right lung upper lobe (figure 2 middle panel). Radiographs of the hand demonstrated calcinosis cutis (figure 2 right panel). Antinuclear antibody titers were elevated and sputum smear examination was positive for acid-fast bacilli. A final diagnosis of Erasmus syndrome (diffuse cutaneous systemic sclerosis with silica exposure) and sputum smear-positive pulmonary tuberculosis was made. Figure?2 (Left panel) CT scan of the thorax (mediastinal window section) demonstrating calcification in mediastinal lymph nodes. (Middle panel) CT scan of the thorax lung window sections demonstrating a thin-walled cavity with surrounding nodules in right upper ... The Erasmus syndrome describes the association of generalised progressive systemic sclerosis following exposure to silica with or without silicosis.1 Our patient had a strong history of silica exposure from cement dust and radiological signs in the form of mediastinal lymph node calcification. Silica exposure is a strong risk factor for the development of systemic sclerosis, and the features of silica associated systemic sclerosis are clinically, serologically and immunologically Crizotinib indistinguishable from idiopathic scleroderma.2 Also, silica exposure even without silicosis is a strong risk factor for the development of pulmonary tuberculosis. To the best of our knowledge, this is the first case report of coexistence of Erasmus syndrome with active pulmonary tuberculosis. Learning points Erasmus syndrome refers to the presence of generalised progressive systemic sclerosis following silica exposure, with or without silicosis. Patients with silica exposure are at high risk for the development of pulmonary tuberculosis, and the risk can persist even following the cessation of exposure. Footnotes Competing interests: None. Patient consent: Obtained. Provenance and peer review: Not commissioned; externally peer reviewed.""Cold-induced urticaria (CU) is a subtype of physical urticaria initially described by Boudron in 1866.1 Physical urticaria account for 25% of all cases of chronic urticaria (ie, urticaria that lasts at least 6?weeks). Six to 34% of individuals with physical urticaria have CU.2 3 Naturally, higher frequency tends to be observed in areas with colder environments.