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In addition to the values for fracture load, Table 1 shows the values for stiffness Crizotinib solubility dmso as well as energy to failure. Values obtained from areal and vBMD measurements as well as for the biometric and geometric parameters are shown in Table 2. Correlation analysis showed that there was a significant correlation between DXA and pQCT-values at the femoral neck (0.854, p?selleck screening library and the fracture load of femoral neck fractures was not found (Fig. 5). Correlation analysis for biometric and geometric parameters detected a significant correlation between body weight, body height, femoral head diameter, and femoral neck length on the one side and fracture load on the other side. There was no correlation between neck-shaft-angle and fracture load. These findings were irrespective of the fracture type (Table 4). Comparing the predictive value of biometric and geometric parameters as well as areal and volumetric BMD measuring techniques on the mechanical strength of the proximal human femur is of significant importance in the prevention of osteoporotic femur fractures. The correlation analysis for densitometric parameters versus fracture UGT1A7 load revealed a highly significant correlation between several densitometric parameters and the fracture load of pertrochanteric fractures. In this regard DXA BMD trochanter (g/cm2) emerged to be the best predictor of pertrochanteric fracture load with R2?=?0.824, however, a correlation between densitometric parameters and the fracture load of femoral neck fractures was not found. The predictive nature of a low BMD has been reported for femoral neck fractures,[23-25] but could be confirmed by Heini[19] just for the trochanteric region and the simulated fall on the greater trochanter. We can confirm this in the presented distinct larger cohort. In contrast to several ex vivo studies indicating that vBMD measured by pQCT has the highest predictive value for mechanical strength of cancellous bone of the proximal and diaphyseal femur,[8-10, 13] we recommend that DXA BMD trochanter should be or remain the focus clinically which, however, is already widely used in standard testing setups. This counts particularly for those elderly osteoporotic people with medical and neurological disorders who are prone for falls and dominantly obtain pertrochanteric and lateral femoral neck fractures. Wachter et al.