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and the LOOCV and repeatability analyses were repeated. The cross-sectional analyses were repeated for M = 4 and 18 dB. All analyses were performed with SAS 9.2 (SAS Institute, Cary, NC, USA) STATA 11.3 (StataCorp LP, College Station, TX, USA), and MATLAB 8.2 (MathWorks, Natick, MA, USA), and a level of 0.05 was used for all significance tests. Results HOV Modeling and Visualization Displayed in Figures 2 and ?and33 are example renderings of the HOV surface models for two patients with different distributions of field loss, one with peripheral field loss from RP and LDN-193189 cell line the other with a ring scotoma from early PCRP. Models in the DLS and defect spaces are shown. For comparison, data from each patient's visual field exam also are depicted using conventional display methods. The conventional indices MS and MD, the volumetric indices VTOT, V30��, DTOT, D30��, and the ratio V30��/VTOT are presented in Figures 2 and ?and3,3, and a volumetric measurement diglyceride of the ring scotoma is presented for the field in Figure 3. The 3-D topographic representations generated by VFMA show the HOV contours and enhance the subtle variations in the visual fields. Figure 2 Comparison of different visualizations and indices of a static perimetry exam from a 63-year-old patient with mild autosomal dominant retinitis pigmentosa from the frameshift mutation, NM_006,269.1:c.3157delT(P.Tyr1053ThrfsX4) of RP18 in association with ... Figure 3 Comparison from a patient with autosomal dominant pericentral retinitis pigmentosa in association with a reported heterozygous mutation in NR2E3,27 NM_014,249.2: c.166G>A(P.G56R), and a second heterozygous variation, NM_005,802.3:c.2643C>G( ... The cross-validation results are presented in Table 2. The TPS interpolator showed good performance with large d values indicating high accuracy, and also good consistency with similar R2 values and similar d values in each subject group. By comparison, the performance of the NN interpolator was lower and less consistent among groups. The R2 and d values from the VFMA TPS interpolator were significantly larger than Apoptosis inhibitor those from the NN interpolator, overall (P