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Freezing in all experiments was expressed as a percentage of the total duration of the tone presentation. On the day following conditioning, rats were divided into two groups. One group of rats received a memory retrieval (Reactivation group; Fig. 2A) trial followed by intra-LA infusions with ISO (n=9) or SAL (n=11). Another group of rats received either intra-LA infusions of ISO (n=5) or SAL (n=6), without explicit memory retrieval (No Reactivation group; Fig. 2A). On the following day, all animals received an extinction test. Procedures were the same as in Experiment 1 except that rats were implanted with cannulae outside of the LA and received drug (or vehicle) infusions 2?mm dorsal to the LA Cobimetinib research buy (ISO: n=7; SAL: n=7; Fig. 2B). Procedures were the same as in Experiment 1 except that the memory extinction test was performed 3?hr following drug (or vehicle) infusions (ISO: n=7; SAL: n=7; Fig. 2C). On the day following training, rats received a memory retrieval trial followed by intra-LA infusions PD-1/PD-L1 inhibitor 2 of ISO (n=19), PRO (n=19), or SAL (n=10). Forty-eight hours later, all rats received a second retrieval trial followed by intra-LA drug (or vehicle) infusions. All rats that received SAL infusions during the first retrieval trial were infused with saline again (SAL-SAL: n=10). Half of the rats that had been infused with ISO following the first memory retrieval trial were infused with SAL (ISO-SAL: n=9), whereas the other half were infused with PRO (ISO-PRO: n=10). Rats that received PRO infusions following the first retrieval trial were also divided into two groups following the second memory retrieval. One group was infused with SAL (PRO-SAL: n=10), whereas the other group was infused with ISO (PRO-ISO; n=9). Data were analyzed using Student's t-test for independent samples, or a two-way analysis of variance (ANOVA) followed by Tukey's HSD post hoc test, and significance levels were set at PALG1 the other group received infusions without memory reactivation (No Reactivation group). During memory reactivation, both SAL and ISO groups expressed comparable levels of freezing (SAL=63.9%, ��5.5; ISO=65.9%, ��5; P>.05) (Fig. 2A). Immediately after rats received bilaterally intra-LA infusions of either ISO or SAL. Forty-eight hours later, all rats received an extinction test. Freezing during the CS presentation was measured and scored for analysis. The results from the ANOVA indicated a significant Reactivation��Drug interaction (F(1,33)=10.76, P