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Tissue culture polystyrene (TCPS) served as a control substrate. Human osteogenic cells (HOB-c) were cultivated on the respective substrates. After 24 hrs, 48 hrs, 72 hrs, 7 d, 14 d and 21 d, cell count was assessed as well as osteogenic cell differentiation utilizing cellular Quantitative Immuno-Cytochemistry (QIC) assay for collagen type I (COL), alkaline phosphatase (AP), osteopontin (OPN) and osteocalcin (OC). Data were normalized GDC-0973 solubility dmso with respect to internal controls. Results: In contrast to the other modified Ti disks, modSLA stands out due to low surface carbon contamination. TCPS and PT surfaces preserved a rather immature, mitotic active osteogenic phenotype (high proliferation rates, no increase of OC production), SLA and especially modSLA surfaces promoted the maturation of osteogenic precursors into post-mitotic osteoblasts. In detail, modSLA resulted in lowest cell proliferation rates, but exhibited highest expression rates of OC. Discussion: Our results, which confirm previous studies, reveal long-term promotion of osteogenic cell maturation by topography Aldosterone (micron and submicron scale roughness) and surface hydrophilicity. To cite this article: Klein MO, Bijelic A, Toyoshima T, G?tz H, von Koppenfels RL, Al-Nawas B, Duschner H. Long-term response of osteogenic cells on micron and submicron-scale-structured hydrophilic titanium surfaces: sequence of cell proliferation and cell differentiation. Clin. Oral Impl. Res. 21, 2010; 642�C649. Selleckchem Natural Product Library doi: 10.1111/j.1600-0501.2009.01883.x ""Aim: The aim of the present study was to evaluate if the use of deprotenized bovine bone mineral (DBBM) and collagen barrier membranes (CM) in combination with mandibular bone block grafts could reduce bone block graft resorption during healing. Methods: A prospective randomized controlled study has been designed. Twenty-two ridges presenting horizontal alveolar deficiency (crest width