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All patients had a doctor's diagnosis of asthma and bronchial hyper-responsiveness, defined as a provocative concentration causing a 20% fall in FEV1 (PC20) methacholine?find more of their asthma before complete discontinuation for 3?weeks, they were asked to visit the Palbociclib hospital earlier. Patients experiencing an exacerbation for which an oral prednisolone course was necessary were not included. In study 3, inhaled corticosteroids were discontinued for 4?weeks before the measurements. In study 2, patients were not required to stop inhaled corticosteroids. In Table?2, the number of patients who still used inhaled corticosteroids at the time of the measurements is presented. 42 (20) N?=?207 2.9 (2.2�C3.5) N?=?212 77 (61�C92) N?=?212 0.26 (0.02�C7.31) N?=?166 0.35 (0.02�C5.74) N?=?33 9.8 (0.02�C640) N?=?124 14.5 (0.02�C640) N?=?50 2.27 (0.27�C8.33) N?=?124 1.02 (0.04�C9.77) N?=?49 0.27 (0.18�C0.43) N?=?122 0.21 (0.13�C0.33) N?=?49 3.3 (1.0�C8.5) N?=?115 0.5 (0.2�C4.9) N?=?40 3.4 (2.5�C4.4) N?=?122 4.2 (3.3�C5.0) N?=?49 36 (22�C60) N?=?115 52 (39�C70) N?=?40 We collected the following available data: BMI, FEV1, PC20 methacholine/histamine, PC20 adenosine 5��-monophosphate (AMP) and inflammatory cell differential counts in sputum and blood. We pooled individual patient data from all four studies, and duplicates were removed. Five patients were excluded because either their weight or height could not be retrieved. The corticosteroid treatment response in obese and nonobese patients was analyzed in study 1. In this study, all 118 patients were treated with either 500?��g/day fluticasone, 2000?��g/day fluticasone or 30?mg/day prednisolone for 2?weeks. More information Cilengitide about the design of this study can be found in the original publication or in the Appendix S1 and Figure S1 [22]. In all four studies, spirometry was performed according to international guidelines, and reference values were obtained from the study of Quanjer et?al [27]. Provocation tests were performed with a 2-min tidal-breathing method. Patients inhaled increasing concentrations of a direct stimulus, either histamine (0.03�C32?mg/ml) or methacholine (0.03�C16?mg/ml), or the indirect stimulus AMP (0.04�C320?mg/ml). The challenge was discontinued when FEV1 had fallen by 20% or more from the prechallenge level or when the highest concentration had been administered.