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It is not clear if they contribute to the lack of control and severity. There are currently no strategies to investigate this by decreasing neutrophil numbers in the airways. To investigate the safety and efficacy of SCH527123, a selective CXCR2 receptor antagonist, in patients with severe asthma and increased number of neutrophils in sputum. In a randomized, double-blind, parallel study, patients with severe asthma and sputum total cell count ?40% were randomized to SCH527123, 30?mg daily PO (n?=?22) or placebo (n?=?12) for 4?weeks. Primary end-points were safety and change in sputum and blood neutrophil counts. Secondary end-points were change in asthma control questionnaire (ACQ) score, minor and major exacerbations, spirometry Selleckchem Dabrafenib and sputum neutrophil activation markers. The SCH 527123 caused a mean SCH772984 price reduction of 36.3% in sputum neutrophil percentage compared to a 6.7% increase in the placebo arm (P?=?0.03). The mean absolute neutrophil count in blood was reduced by 14% at the end of 4?weeks, but recovered by the 5th week. There were no differences in the overall rates of adverse events among the groups. There were fewer mild exacerbations (1.3 vs. 2.25, P?=?0.05) and a trend towards improvement in the ACQ score (mean difference between groups of 0.42 points, P?=?0.053). No statistically significant changes were observed in forced expiratory volume in 1?s (FEV 1), sputum myeloperoxidase, IL8 or elastase. The SCH527123 is safe and reduces sputum neutrophils in patients with severe asthma. This new treatment provides an opportunity to investigate the role of neutrophils in severe asthma with potential clinical benefits. Larger studies of longer duration are needed to evaluate the impact on other outcomes of asthma including exacerbations.""Background A novel nutritional formula (NNF) enriched in eicosapentaenoic (EPA) and ��-linolenic fatty acids and antioxidants reduces airway inflammation and improves clinical outcomes in critically ill patients, but NNF has not been evaluated in chronic inflammatory diseases such as persistent asthma. Objective To evaluate the efficacy, compliance, and safety of NNF in asthmatic children. Methods Children, 6�C14 years of age, with mild to moderate persistent asthma, on as needed albuterol alone, were randomized to receive daily NNF (n=23) Ritonavir or control formula (n=20) for 12 weeks, with multiple assessments of asthma control, spirometry, measures of airway inflammation, formula tolerance, and adverse events. Results Daily consumption of either NNF or a control formula showed improvement in asthma-free days over time (P=0.04) but there was no difference between groups. However, the NNF group had lower exhaled nitric oxide levels compared with the control group at weeks 4, 8, and 12 (P