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8%, 67.0%, and 63.3% in patients with moderate and 81.0%, 64.6%, and 50.2% in patients with severe RI (P = .87, by log-rank; Fig 1). Cumulative rates of repeated revascularization were 20.7%, 27.3%, and 46.4% in patients with normal renal function, 21.1%, 37.5%, and 40.3% in patients with moderate and 19%, 33.7%, and 45.7% in patients with severe RI (P = .98, by log-rank; Casein kinase 2 Fig 2) after 2, 6, and 12 months. Noncumulative surgical and endovascular reintervention rates are specified in Table III. Immediate hemodynamic improvement according to ABI and oscillometric reading did not differ among groups and was obtained in 72.2%, 79.1%, and 83.3% in patients with normal renal function, moderate and severe RI, respectively (P = .39, by ��2 test). Accordingly, no differences were found among groups regarding sustained hemodynamic improvement at 2, 6, and 12 months (P > .07, by ANOVA test; Table III). Minor amputations were necessary in 10.7%, 13.4%, and 20.2% of patients with normal renal function, respectively, in 14.0%, 15.7%, and 17.9% with moderate and in 4.8%, 9.5%, and 19.6% of patients with severe RI (P = .96, by log-rank) after 2, 6, and 12 months. Accordingly, major amputations were necessary in 9.9%, 18.2%, and 20.8% of patients with normal renal function, in 9.9%, 22.6%, and 24% with moderate, and in 12.5%, 16.7%, and 21.1% of patients with severe RI (P = .83, by log-rank; Fig Vismodegib chemical structure 3). A total of 11 CLI patients (5.3%) died within 30 days of revascularization (fatal myocardial infarction, n = 4; fatal stroke, n = 2; sepsis, n = 2; tonsillar carcinoma, n = 1; breast cancer, n = 1; multiorgan failure, n = 1). Thirty-day mortality rates in patients with normal, moderate, and severe RI dysfunction were 4.6%, 5.8%, and 8.3%, respectively (P = .76, ANOVA-test). Mortality rates at 2, 6, and 12 months were 8.4%, 17.4%, and 26.5% in patients with normal renal function, 9.6%, 17.6%, and 30.1% in patients with moderate renal dysfunction, and 17.5, 26.6%, and 31.9% in patients with severe RI (P = .77, by log-rank; Fig 4). In multivariate analysis adjusted for age, gender, diabetes mellitus, arterial hypertension, cigarette smoking, coronary heart disease, cerebrovascular disease, segment of endovascular revascularization (iliac vs femoral vs infrageniculate), and disease severity (ischemic rest pain vs skin lesions) at baseline, it was Trichostatin A order shown that creatinine clearance at baseline is an independent predictor for increased mortality (hazard ratio [HR], 1.016; 95% CI, 1.001-1.031; P = .036, by Cox proportional hazards regression). Moreover, age (HR, 1.12; 95% CI, 1.061-1.189; P