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Third, the two types of MA were evaluated with only a short interval between procedures. Whether our findings will also hold for patients with more severe heart failure requires further investigation. In conclusion, we have shown that the occurrence of dobutamine-induced MA is a potentially useful clinical predictor of poor prognosis in ambulatory patients with IDCM in sinus rhythm. Fig. S1 Left ventricular pressure waveforms during atrial pacing at 120?b.p.m. and after infusion of 10?��g/kg per min dobutamine for representative patients in the three study groups. Please note: Wiley-Blackwell are not responsible for the content or functionality of any supporting materials supplied by the authors. Any queries (other than missing material) should be directed to the corresponding author for the article. ""The dominant RN? mutation Montelukast Sodium in pigs results in excessive glycogen storage in skeletal muscle. The mutation is situated in the PRKAG3 gene, which encodes a muscle-specific isoform of the AMP-activated protein kinase (AMPK) ��3 subunit. AMPK is an important regulator of carbohydrate and fat metabolism in mammalian cells. The aim Akt inhibition of the present study was to examine the effect of exercise on glycogen synthesis signalling pathways in muscle and to study enzyme activities of importance in carbohydrate metabolism in pigs with or without see more the PRKAG3 mutation. Glycogen content, metabolic enzyme activities and expression or phosphorylation of signalling proteins were analysed in skeletal muscle specimens obtained at rest, after a single treadmill exercise bout and after 3 h recovery. The PRKAG3 mutation carriers had higher glycogen content, a tendency for lower expression of AMPK (P