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Fifteen patients did not receive CRT. Five patients were not evaluable. RTQAs of the 115 patients were 24% PP, 50% MID and 16% MAD. MAD Protease Inhibitor Library were mainly PTV coverage inhomogeneities (Dmin 110%), non-respect of required margins around the GTV, and a too high dose (V30 > 45%) received by the liver. Impact of RTQAs on survival and toxicity will be presented at the meeting. Quality assurance of complex radiation therapy was better than in previous large studies but needs improvement. Its impact on toxicity and outcome will be presented. ""To generate a consensus RTOG atlas for CT and for MR image-based cervical cancer brachytherapy by analyzing variability in contouring. RTOG Gynecologic Cancer Steering Committee members received 3 cervical cancer cases to contour. Each case had a 3T MRI at diagnosis, an MRI and a CT performed at the time of brachytherapy within an hour of insertion, and clinical drawings based on the MRI at diagnosis and at the time of brachytherapy. Instructions mandated that CT contouring should be done first without viewing the MRI at the time of brachytherapy. For CT contouring, physicians drew a CTV-cervix that included the cervix and any notable parametrial extension at the time of brachytherapy, but not the entire parametrial region if not BGJ398 order involved. The cervix contours started at the level of the applicator. MR contouring followed the GEC ESTRO guidelines for delineating an HR-CTV. The clinical cases were then analyzed for consistency and clarity of target delineation using an expectation maximization algorithm for simultaneous truth and performance level estimation (STAPLE), with kappa statistics as a measure of agreement between participants. The conformity index (CI), defined as the ratio between the common (mean) and encompassing (union) volume of a given pair of contours was calculated for each of the six data sets. Dice coefficients were generated to compare CT and MR contours of the same case. The Dice coefficient is the volume of the intersection divided by the average volume of the two structures. A total of 23 physicians contoured as part of this protocol. Results are shown in the Table. The mean tumor volume was smaller on MR than CT (p Unoprostone and were slightly higher for CT. Sensitivity and specificity were similar between CT and MR, indicating very little apparent difference in contours. Conformity index was slightly higher for CT compared to MR, indicating a higher level of agreement on CT. Dice coefficients of the 95% consensus volumes comparing CT to MR were 59% for case 1, 71% for case 2 and 88% for case 3. MRI contoured volumes are consistently smaller than CT volumes. However, CT has a higher level of agreement that may be due to the more distinct contrast visible on the images at the time of brachytherapy.