Thymidine kinase -- A Extensive Analysis On What Really works And The things that Doesn't

In the heterozygotes there were 132.4 Ki-67 positive cells per 40?�� field compared to 71.5 positive cells in the wild type (P Thymidine kinase mice. The total percent area occupied by metastases in the wild-type lungs was 7.4% versus 1.4% for heterozygous lungs (P Q-VD-Oph in vivo in a C57BL6 mouse [33]. The Fli1��CTA/��CTA mice lack the C-terminal regulatory domain of Fli1 involved in activation or repression of gene transcription, thus affecting a subset of Fli1 functions. No difference in tumor initiation was seen between the Fli1��CTA/��CTA and the wild-type mice; however, the tumor growth rate was significantly different between the two genotypes (Figure?5A). The rate of growth for the wild type was 29 mm3/day and for the Fli1��CTA/��CTA it was 43 mm3/day (P = .03). Also, the number of lung metastases was greater in the Fli1��CTA/��CTA (2.29 +/? 0.78) than in the wild type (0.25 +/? 0.16; P = .017) ( Figure?5B). The EO771 cells were also orthotopically injected into C57BL6 Fli1 heterozygous mice and wild-type mice. As with the Fli1��CTA/��CTA mice, the tumors in the Fli1?+/? mice grew faster than in the wild type BAY-61-3606 (wild type 52.5 +/? 5 mm3/day; Fli1?+/?, 71.1 +/? 6 mm3/day; P = .02) ( Figure?5C) and survival time was greater for the wild type (median survival, for wild type = 42 days; for Fli1?+/? = 37 days; P