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00008), with a difference in recurrence time of 10.5?years. Similarly, high cytoplasmic S1P1 and cytoplasmic ERK-1/2 expression (p?=?0.004) and high cytoplasmic S1P3 expression and cytoplasmic ERK-1/2 expression (p?=?0.004), were associated with shorter recurrence time. These results support a model in which the selleck products interaction between SK1, S1P1 and/or S1P3 and ERK-1/2 might drive breast cancer progression and this therefore warrants further investigation. ""A retrospective study was carried out comparing three cohorts of consecutive patients diagnosed with DCIS via the NHSBSP in the East Midlands region. Diagnostic, treatment and follow-up outcome data was collected by individual patient case notes review, and where necessary by contacting general practitioners. Kaplan�CMeier survival analysis was performed using SPSS. Histological excision margins were increasingly clear over time 88% (88/93), SB203580 cost 91.5% (94/97) and 98% (00/03). The overall local recurrence free survival rate was identical for both earlier periods with 92% at 5?years but improved to 96.1% over 2000/03. 40�C56% of all local recurrences were invasive; 13/23 (88/93), 14/26 (94/97), and 8/21 (00/03). Use of tamoxifen within the three cohorts was similar (44�C46%) and made no significant difference to rates of local or contralateral recurrence free survival. Significant differences in local recurrence rates by operation type were observed (see Table 1). Conclusion: Local recurrence rates after breast conserving surgery for screen detected DCIS have reduced over time. This is likely to be related to higher rates of non-operative diagnosis, combined with improved histological assessment (grading and margin status), more aggressive surgery and increasing use of radiotherapy. ""Background: The aim of our study was to assess various risk factors for local recurrence (LR) in patients undergoing breast conservation surgery (BCS) for ductal carcinoma in situ (DCIS). Materials and methods: Retrospective case note review between January 1975 and June 2008. In our hospital a margin of ?10?mm is considered acceptable. Patients were divided into three groups based on pathological margin (Alizarin ?10?mm). Cox regression model for multivariate analysis of local recurrence was used with variables with significant P values (