What Is Happening With The MAPK

QTLs were deemed ��known�� if they had been previously linked (with LOD��3 or p-value reported as genome-wide significant) to any lipid trait or contained a SNP previously associated (p-values?��?5E-08) with a lipid trait in their 1-LOD drop support interval. The QTLs with both significant linkage and association evidence were 1p33 (linkage: [39]; lipid-associated genes (see Table?3): CYP4A11, PCSK9, and GOT2P1-RPSAP20) and 2q14.1 (linkage: [35]; lipid-associated genes: INSIG2 and LOC84931). The QTLs EPZ5676 in vitro on chromosomes 6q12 [40], 9p21.3 [35]?and?[36], 11p13 [41], 18q22.3 [41], and 21q22.3 [42] had significant linkage evidence only, while the QTLs on 6p22.3 (cited genes: HFE, ZNRD1-AS1,WASF5P-HLA-B, HCG26-MICB, AGPAT1-EGFL8, HLA-DRA, COL11A2, SPDEF-RPL7P25, KCNK17), 8p12 (DUSP4-RPL17P33), 8q13.1 (UBXN2B-CYP7A1), and 17q22 (VMP1, APOH-PRXCA, and ABCA8) had significant association evidence only Selleckchem LY2109761 (see Table?3). Three of our novel loci (on chromosomes 2q24.1, 4q21.21, and 12p11.23) contained SNPs with some (p?MAPK bringing the total number of novel loci detected to seven. We also identified ten known lipid loci with interactions that lacked even suggestive evidence without interactions, showing the impact that age-dependent effects may have on the consistency of results across populations. Other investigations have reported gene�Cage interactions in three of our known QTLs [6], [11]?and?[13], lending some credibility to the results from our modeling method. Known loci on chromosomes 1p33, 2q14.1, and 6p22.3 contained SNPs (in PCSK9 [11], INSIG2 [13], and an intergenic region [6], respectively) that yielded nominal evidence (p-value?