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Ground sections were prepared from 12-week healing biopsies, and histomorphometry and Doxorubicin molecular weight fluorescence analysis were performed. In the groups with thin gingiva, numerically greater buccal bone loss was observed, while there were no differences between grafted and nongrafted sites. A numerically higher rate of mineralization was observed for the grafted sites, as compared with the nongrafted sites, at 12 weeks. A thin buccal bone plate leads to higher bone loss in extraction sockets, even with flapless surgery. The gingival thickness or the use of a graft material did not prevent buccal bone resorption in a naturally thin biotype, but modified the mineralization process. ""The aim of this study was to investigate the effect of implant shape and screw pitch on microdamage in bone during insertion of dental implants. Thirty custom-made implants (length, 10?mm; selleck inhibitor diameters, 4.1?mm; cylindrical, tapered, and taper-cylindrical shapes; screw pitches, 1.25 and 0.8?mm; classified as 1.25C, 0.8C, 1.25T, 0.8T, 1.25TC, 0.8TC) were placed with a surgical device in the mandibles of eight goats. Two implant sites were prepared in the edentulous area on each side of the mandible. Implants were placed in a randomized order. Immediately after placement of the implants, the bone blocks with the implants were collected, bulk stained with basic fuchsin, embedded in methyl methacrylate, and sectioned. Histomorphometric quantification of the microcrack length (Cr.Le, ��m); microcrack surface FARP1 density (Cr.Le/B.Ar, ��m/mm2), and damaged bone area fraction (DB.Ar/B.Ar, %) were measured. The Cr.Le, Cr.Le/B.Ar, and DB.Ar/B.Ar values of 0.8TC group were 80.96?��?17.55, 478.75?��?51.85, and 4.40?��?0.36, respectively. All these parameters of microdamage induced by 0.8TC were significantly lower than those induced by other five types of implants (p?