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3%. The first episode of pneumothorax occurred at the age of 33.8?��?13.2 years. A total of 530 episodes of pneumothorax was noted in the entire study population. Pneumothorax occurred most frequently between the late 20s and early 30s. A bilateral and simultaneous pneumothorax episode was demonstrated in 12.5% of the probands. Results?In the cohort of BHDS whose pulmonary manifestation prompted selleck kinase inhibitor the diagnosis, the frequencies of skin and renal manifestation were low. In this clinical setting, family history of pneumothorax is common and a bilateral and simultaneous episode of pneumothorax may develop frequently. NITESH GUPTA, NITIN GOEL, RAJ KUMAR Department of Respiratory Allergy and Applied Immunology, Vallbhbhai Patel Chest Institue, University of S3I-201 in vivo Delhi, Delhi, India Background and Objective?Exhaled nitric oxide (FENO) and nasal nitric oxide (n NO) measurement is an area of ongoing research in the study of airway inflammation. The atopic status is known to influence the levels of FENO and n NO. This study was undertaken to study the relationship between the noninvasive methods of nitric oxide measurements in bronchial asthma and allergic rhinitis and their correlation with atopic profile of Indian population. Methods?Ninety subjects were recruited for the study comprising 25 each of bronchial asthma (BA), allergic rhinitis (AR), bronchial asthma with allergic rhinitis (BA-AR) and 15 healthy controls. These were assessed for atopy and exhaled breath analysis of nitric oxide. The measurements of FENO and n NO levels was done using NIOX chemiluminescence analyzer. Atopy was assessed by skin prick testing (SPT) against 58 common aero-allergens and subjects with atleast 1 positive SPT were labeled as atopic. Results?The FENO levels in BA-AR (41.44?��?29.9?ppb) and BA (34.96?��?17.2?ppb) groups were higher in comparison to control (12.73?��?7.8?ppb) (p?Quinapyramine correlation (p?=?0.07). Conclusion?FENO is a non-invasive marker of airway inflammation. Also, FENO levels correlate with presence and degree of atopy in BA and AR. Simultaneously, n NO could be a surrogate marker of rhinitis. ""3352" "The mammalian blood system, containing more than 10 distinct mature cell types, stands on one specific cell type, hematopoietic stem cell (HSC). Within the system, only HSCs possess the ability of both multipotency and self-renewal. Multipotency is the ability to differentiate into all functional blood cells. Self-renewal is the ability to give rise to HSC itself without differentiation.