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In each individual mouse increases in rCBF at the stimulation site under stimulus-condition as compared to control CASK could readily be observed in SPECT/CT data sets (Fig.?2). The mean lever press rates were 121.2 per min (SEM 15.1). Mean normalized 99mTc-content below the stimulation electrode as calculated from the VOIs in the normalized SPECT-data of the five mice increased by 38.6% as compared to control conditions. Tracer uptake and mean lever press rates were correlated (r?=?0.63), but with the sample size of n?=?5 the correlation did not reach statistical threshold. Differences in 99mTc-content were likewise immediately evident at the tip of the electrode used for stimulation compared to the non-stimulating electrode in the same animal. Electrode positions varied between animals (Fig.?3) but in the group analysis, nevertheless, a significant increase (p?this website ipsilateral to the stimulation site in the accumbens nucleus (Fig.?4) and in a region medial to the mammilothalamic tract at the level of the zona incerta and ventromedial thalamus. Significant deactivations (p?selleck screening library (SEM 5.51). The VOI-based analysis revealed a statistically insignificant (t?=?1.46) increase in normalized 99mTc-content of 3.6% under stimulus-conditions versus controls. ChR2-expression in the VTA was confirmed histologically in all animals. Significant increases (p?