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(Створена сторінка: Admission to intensive care unit (ICU) in patients with cancer would make some distress in emotion and quality of life. The decision making is difficult to admi...)
 
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Admission to intensive care unit (ICU) in patients with cancer would make some distress in emotion and quality of life. The decision making is difficult to admit ICU in lung cancer patient. The predictive factors of outcome will be needed. We reviewed the clinical outcome and characteristics of patients with lung cancer who admitted ICU retrospectively. Methods?We retrospectively collected clinical data of patients with lung cancer who admitted ICU from January 2010 to November 2011. Causes of admission, use of mechanical ventilation, presence of do-not-resuscitate, mortality were included. Postsurgical care was excluded in analysis. Results?One hundred thirty one patients were admitted in ICU. For postoperative care ninety three [http://www.selleckchem.com/products/ABT-888.html www.selleckchem.com/products/ABT-888.html] patients were admitted in surgical ICU and excluded. We analyzed thirty eight patients of lung cancer. NSCLC patients were 34 (89%) and SCLC patients 4 (11%). 25 patients (66%) were inoperable stage (stage IIIB, IV). Causes of admission were acute respiratory failure (78%), cardiovascular disease (8%), gastrointestinal bleeding (8%) and neurologic disease (5%). The mortality of ICU was 53% (20/38). Seventeen patients and family noticed the code of do-not-resuscitation after ICU admission. Twenty nine (79%) patients were received mechanical ventilation and 25 of 29 patients were dead during ICU care. Conclusion?In advanced lung cancer patients, ICU care would not be [http://en.wikipedia.org/wiki/DDR1 DDR1] needed in some conditions. The model of ICU mortality in lung cancer should be established for the purpose of well-dying care. JYI LIN WONG1, SIEW TECK TIE1, KONG LEONG YU2, PEY JIE VOON2 1Department of Medicine, Sarawak General Hospital, 2Onoclogy Unit, Sarawak [http://www.selleckchem.com/products/Methazolastone.html learn more] General Hospital Introduction?Incidence of lung malignancy is rising due to prevalence of smoking. Adenocarcinoma is the most common histological subtype worldwide and in Malaysia. Its treatments have evolved from the conventional chemotherapy to targeted therapy. EGFR mutation is an established predictive factor for the use of tyrosine kinase inhibitor (TKI). While EGFR mutation has been more commonly associated with Asians, its prevalence among different ethnic group among Asians has not be established. Methods?A retrospective study. All patients seen in respiratory unit between Nov 2011 to Feb 2013 whom were suffering from lung malignancy were included. Their characteristics were obtained from clinic cards. Results?A total of 93 patient was included in the analysis. Adenocarcinoma was found in 53% (n?=?49) of the cases and squamous cell carcinoma in 25% (n?=?23) of the cases. Overall, lung carcinoma suffers are more likely to be male (69%, n?=?64) and smokers (56% n?=?52). However, for subtype adenocarcinoma female (OR 2.48 p?=?0.048) and non-smokers (OR 7.09, p?
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Mesenchymal stem cells (MSCs) are an attractive source for therapy; [http://www.selleckchem.com/products/ABT-888.html learn more] reduced ethical concern, ease in expansion, as off-the-shelf stem cells. MSCs exert immune suppressive properties, providing them with the potential for immune suppressive therapy such as autoimmunity, asthma, allergic rhinitis and graft versus host disease. In addition, MSCs, as well as other stem cells, can be applied for bone and cartilage repair, cardiovascular disease, and neural repair/protection. The data thus far with MSCs are mixed. This review discusses the immune-enhancing properties of MSCs to explain the possible confounds of inflammatory microenvironment in the MSCs therapy. Although this review focuses on MSCs, [http://www.selleckchem.com/products/Methazolastone.html selleck compound] the information can be extrapolated to other stem cells. The review summarizes the biology of MSCs, including multilineage differentiation potential, transdifferentiation capability, and immunological effects. We emphasize the key concepts that may predict the use of these cells in medicine, namely, the application of these cells from the bench to the bedside. Prospects on immunotherapy, neuroregeneration, and cardiovascular repair are used as examples of tissue repair. Clin Trans Sci 2011; Volume 4: 380�C386 ""4005" "Hyponatremia is a common electrolyte disorder in patients with heart failure (HF) associated with cognitive dysfunction and increased mortality and rehospitalization rates. Loop diuretics worsen renal function, produce neurohormonal activation, and induce electrolyte imbalances. Lixivaptan is a selective, oral vasopressin V2-receptor antagonist that improves hyponatremia by promoting electrolyte-free aquaresis without significant side effects. The Treatment of Hyponatremia Based on Lixivaptan in NYHA Class [http://en.wikipedia.org/wiki/DDR1 DDR1] III/IV Cardiac Patient Evaluation (BALANCE) study is a randomized, double-blind, placebo-controlled, phase 3 trial designed to evaluate the effects of lixivaptan on serum sodium in patients hospitalized with worsening heart failure (target N= 650), signs of congestion and serum sodium concentrations

Поточна версія на 00:33, 25 червня 2017

Mesenchymal stem cells (MSCs) are an attractive source for therapy; learn more reduced ethical concern, ease in expansion, as off-the-shelf stem cells. MSCs exert immune suppressive properties, providing them with the potential for immune suppressive therapy such as autoimmunity, asthma, allergic rhinitis and graft versus host disease. In addition, MSCs, as well as other stem cells, can be applied for bone and cartilage repair, cardiovascular disease, and neural repair/protection. The data thus far with MSCs are mixed. This review discusses the immune-enhancing properties of MSCs to explain the possible confounds of inflammatory microenvironment in the MSCs therapy. Although this review focuses on MSCs, selleck compound the information can be extrapolated to other stem cells. The review summarizes the biology of MSCs, including multilineage differentiation potential, transdifferentiation capability, and immunological effects. We emphasize the key concepts that may predict the use of these cells in medicine, namely, the application of these cells from the bench to the bedside. Prospects on immunotherapy, neuroregeneration, and cardiovascular repair are used as examples of tissue repair. Clin Trans Sci 2011; Volume 4: 380�C386 ""4005" "Hyponatremia is a common electrolyte disorder in patients with heart failure (HF) associated with cognitive dysfunction and increased mortality and rehospitalization rates. Loop diuretics worsen renal function, produce neurohormonal activation, and induce electrolyte imbalances. Lixivaptan is a selective, oral vasopressin V2-receptor antagonist that improves hyponatremia by promoting electrolyte-free aquaresis without significant side effects. The Treatment of Hyponatremia Based on Lixivaptan in NYHA Class DDR1 III/IV Cardiac Patient Evaluation (BALANCE) study is a randomized, double-blind, placebo-controlled, phase 3 trial designed to evaluate the effects of lixivaptan on serum sodium in patients hospitalized with worsening heart failure (target N= 650), signs of congestion and serum sodium concentrations

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