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(найновіші • найдавніші) Переглянути (новіших 50 • старіших 50) (20 • 50 • 100 • 250 • 500).
- 09:28, 25 травня 2018 (різн. • історія) . . (+4346) . . Н Further a lot more differential regulation of exercise by way of RLC phosphorylation states switches backbone from backbone precursors (Further a lot more differential regulation of exercise by way of RLC phosphorylation states switches backbone from backbone precursors) (поточна)
- 05:07, 5 травня 2018 (різн. • історія) . . (+4812) . . Н The differences in RER values in between lean and overweight dam offspring were greater suggesting impaired metabolic versatility (The differences in RER values in between lean and overweight dam offspring were greater suggesting impaired metabolic versatility) (поточна)
- 09:22, 2 квітня 2018 (різн. • історія) . . (+4356) . . Н On the other hand SDHCS83G substitution representing only of the mutants at the only substitution kind noticed (Створена сторінка: [https://en.search.wordpress.com/?src=organic&q=pannus-like pannus-like] tissue, an invasive granulation tissue, has been located in the knees of patients with...) (поточна)
- 11:44, 29 березня 2018 (різн. • історія) . . (+4586) . . Н On the other hand SDHCS83G substitution representing only of the mutants at the only substitution sort observed (Створена сторінка: Though Btk is related with the BCR complicated on the plasma membrane, it has been revealed that Btk is also localized in the nucleus and involved in transcript...) (поточна)
- 10:11, 28 березня 2018 (різн. • історія) . . (+4253) . . Н Apparently other substitutions have been exclusive to the personal compounds employed for assortment (Створена сторінка: The N-terminal area of cThy28 protein one-seventy one), which includes a nuclear localization sign, is not conserved amid human and mouse, even though the C-ter...) (поточна)
- 15:21, 27 березня 2018 (різн. • історія) . . (+4227) . . Н Because the biochemical circumstance of flatworm parasites is really comparable with regards to the thiol redox-dependent pathways (Створена сторінка: The N-terminal location of cThy28 protein 1-seventy one), which contains a nuclear localization sign, is not conserved between human and mouse, even though the...) (поточна)
- 09:28, 20 березня 2018 (різн. • історія) . . (+4140) . . Н Entirely this discovering recommended that the phenylsulfonyl moiety is a new pharmacophore in the layout of TGR inhibitors (Створена сторінка: Systemic administration of three-NPA has been proposed to make memory impairment in rodents, as a single of the symptoms of High definition, which can be more r...) (поточна)
- 13:38, 17 березня 2018 (різн. • історія) . . (+4147) . . Н On the other hand the simple fact that active compounds have been separated into two groups suggests (Створена сторінка: It is worthy famous that oxidative tension is a corner stone in mediating behavioral impairment and memory deficit in age-relevant neurodegenerative disorders....) (поточна)
- 13:19, 17 березня 2018 (різн. • історія) . . (+4233) . . Н This effect could hardly be ascribed to variations in electrophilicity suggesting these substituents (Створена сторінка: The defective lysosomal-autophagosome clearance is associated with Advert pathology, and the result of this examine is also regular with a preceding finding tha...) (поточна)
- 08:37, 15 березня 2018 (різн. • історія) . . (+4437) . . Н Remarkably the lively furoxan derivative was obviously divided from other furoxan derivatives and was clustered (Створена сторінка: In the very first noted RYGB rodent product the whole tummy was remaining intact even though the pyloric sphincter was ligated dilated. This post-operative dila...) (поточна)
- 08:12, 12 березня 2018 (різн. • історія) . . (+4394) . . Н The IMPDH reaction equilibrium strongly favors the ahead reaction and maintains the guanine nucleotide pool (Створена сторінка: In the first noted RYGB rodent model the whole stomach was left intact although the pyloric sphincter was ligated dilated. This publish-operative dilatation of...) (поточна)
- 09:15, 8 березня 2018 (різн. • історія) . . (+4164) . . Н In Mt-GuaB2 is solely accountable for this important operate considering that out of the a few genes encode (Створена сторінка: Systemic administration of three-NPA has been proposed to produce memory impairment in rodents, as one particular of the signs and symptoms of Hd, which can be...) (поточна)
- 12:09, 6 березня 2018 (різн. • історія) . . (+5177) . . Н The latter influence currently being the end result of zoledronate relatively than the one particular of everolimus in the same chondrosarcoma model (Створена сторінка: This course is not tiny, representing approximately 20% of transcripts researched. Our results support the see that there is a gradient of susceptibility to SOX...) (поточна)
- 09:03, 5 березня 2018 (різн. • історія) . . (+5455) . . Н That could possibly end result in enhanced mobile survival and resistance to cancer treatment in reaction to long expression mTORC inhibition (Створена сторінка: The existing perform extends our aforementioned original conclusions by performing two different temperature-monitoring studies in order to evaluated sub-persis...) (поточна)
- 07:08, 27 лютого 2018 (різн. • історія) . . (+5209) . . Н MTOR is a central regulator in mobile procedures upon which tumor cells count and there are expanding dataalteration (Створена сторінка: This class is not tiny, representing around 20% of transcripts analyzed. Our final results help the look at that there is a gradient of susceptibility to SOX re...) (поточна)
- 07:26, 26 лютого 2018 (різн. • історія) . . (+5128) . . Н MTOR is a central regulator in mobile processes on which tumor cells depend and there are growing dataalteration (Створена сторінка: This class is not little, representing roughly 20% of transcripts studied. Our outcomes help the see that there is a gradient of susceptibility to SOX regulatio...) (поточна)
- 10:04, 23 лютого 2018 (різн. • історія) . . (+19) . . м Therefore mTOR represents a possible therapeutic concentrate on and endeavours have been made to build inhibitors distinct for this protein (поточна)
- 10:03, 23 лютого 2018 (різн. • історія) . . (+5262) . . Н Therefore mTOR represents a possible therapeutic concentrate on and endeavours have been made to build inhibitors distinct for this protein (Створена сторінка: In addition, several molecules active in other mobile signal transduction pathways are upregulated, which includes several twin-specificity protein phosphatases...)
- 07:18, 13 лютого 2018 (різн. • історія) . . (+5325) . . Н The most agent inhibitors that mimetize the interactions of thiamine pyrophosphate are oxythiamine and thiamine thiazolone (The most agent inhibitors that mimetize the interactions of thiamine pyrophosphate are oxythiamine and thiamine thiazolone) (поточна)
- 07:07, 13 лютого 2018 (різн. • історія) . . (+5040) . . Н Unfortunately these compounds deficiency selectivity as thiamine pyrophosphate is a frequent cofactor located in numerous enzymes (Unfortunately these compounds deficiency selectivity as thiamine pyrophosphate is a frequent cofactor located in numerous enzymes) (поточна)
- 08:57, 7 лютого 2018 (різн. • історія) . . (+5350) . . Н There is no vaccine offered and regular-ofcare therapy is dependent on a blend of pegylated interferon and ribavirin (Створена сторінка: We analyzed the ability of miR-overexpressing BMMCs to degranulate upon stimulation using b-hexosaminidase action in the supernatant of activated cells as a eva...) (поточна)
- 08:49, 7 лютого 2018 (різн. • історія) . . (+5348) . . Н Our final results recommend that Necdin harbors each tumor suppressive or oncogenic homes relying on the cellular context (Створена сторінка: Finally, it is well worth noting that the curation process of the BindingMOAD database incorporates an info extraction phase that employs a all-natural language...) (поточна)
- 07:41, 6 лютого 2018 (різн. • історія) . . (+5552) . . Н A amount of hurdles continue to be practically ten a long time soon after the preliminary discovery of the efficacy of this kind of agents (Створена сторінка: BMMCs had been 1st labeled with CFSE. Strikingly, not only miR-221-overexpressing cells showed enhanced numbers of adherent cells , but whilst the actin ring be...) (поточна)
- 07:32, 6 лютого 2018 (різн. • історія) . . (+5235) . . Н Our results propose that Necdin harbors both tumor suppressive or oncogenic homes dependent on the mobile context (Створена сторінка: Finally, it is value noting that the curation approach of the BindingMOAD databases incorporates an info extraction action that employs a all-natural language p...) (поточна)
- 10:32, 5 лютого 2018 (різн. • історія) . . (+4973) . . Н Accordingly Necdin could have a prospective position in the transformation procedure involving viral proteins (Створена сторінка: For case in point TSSs four and five of PSMD8 are much better in the heterologous than the endogenous context, and the key TSS three of endogenous WBP11 is weak...) (поточна)
- 12:47, 1 лютого 2018 (різн. • історія) . . (+2049) . . м One promising candidate is Lim domain only known to control the expression of the Ndn gene and that was also upregulated
- 10:17, 31 січня 2018 (різн. • історія) . . (+5118) . . Н One promising candidate is Lim domain only known to control the expression of the Ndn gene and that was also upregulated (Створена сторінка: Furthermore, [http://www.abmole.com/products/doxorubicin.html Doxorubicin] translation from the RPA39 mutant promoter was initiated from the native downstream A...)
- 10:04, 31 січня 2018 (різн. • історія) . . (+4984) . . Н The increase in Necdin expression in reaction to PyLT expression was not triggered by inactivation was dependent (Створена сторінка: We hypothesized that PSIIRC should be a major concentrate on for this kind of engineering and that genetic differences amongst the PSIIRC in thermophiles and me...) (поточна)
- 09:26, 30 січня 2018 (різн. • історія) . . (+4780) . . Н Stimulation of NIH cells with nutlin-3 resulted in the stabilization of p53 creating p21 induction and a gradual expansion arrest (Створена сторінка: Even so presently there is minor evidence for such composite regulatory factors. In this research we recognized an considerable proximal factor with a rigorous...) (поточна)
- 09:44, 26 січня 2018 (різн. • історія) . . (+5059) . . Н To verify that progress arrest acquired in our model was actually studies on the inhibitory action of the viral protein (Створена сторінка: Furthermore, translation from the RPA39 mutant promoter was initiated from the indigenous downstream AUG, but in this scenario there was a important leakage to...) (поточна)
- 08:07, 25 січня 2018 (різн. • історія) . . (+5038) . . Н Outcomes noted here assist this dual operation for Necdin p53-dependent tumor suppressive cell fates (Створена сторінка: Similarly, translation from the RPA39 mutant promoter was initiated from the indigenous downstream AUG, but in this case there was a significant leakage to the...) (поточна)
- 07:57, 25 січня 2018 (різн. • історія) . . (+4947) . . Н Necdin was 1st recognized as a neuronal differentiation marker connected with expansion arrest but has because been identified (Створена сторінка: We hypothesized that PSIIRC should be a main goal for this sort of engineering and that genetic distinctions among the PSIIRC in thermophiles and mesophiles giv...) (поточна)
- 11:48, 23 січня 2018 (різн. • історія) . . (+4846) . . Н Furthermore the expression of Necdin can defend cells from apoptosis in different versions like p53-induced apoptosis (Створена сторінка: Owing to rotation around their glycosidic bonds, cyclic nucleotides exist in equilibrium amongst syn and anti conformations, with cGMP and cAMP favoring syn and...) (поточна)
- 11:58, 19 січня 2018 (різн. • історія) . . (+5195) . . Н Inquiries in regard to bioavailability have plagued the use of curcumin as a possible therapeutic for a variety of many years (Створена сторінка: Pin1 also modulates the turnover of the transcription aspect IRF3 downstream of toll-like receptor three, and Pin1-null mice ended up faulty in generating IFNb...) (поточна)
- 11:52, 17 січня 2018 (різн. • історія) . . (+5244) . . Н App a transmembrane protein is cleaved in two successive proteolytic reactions to release peptide amino acids (Створена сторінка: Pin1 also modulates the turnover of the transcription issue IRF3 downstream of toll-like [http://www.abmole.com/products/byl719.html BYL719 PI3K inhibitor] rece...) (поточна)
- 09:44, 3 січня 2018 (різн. • історія) . . (+6800) . . Н Ventromedial hypothalamic lesion is linked with increased sleep time in rats on snooze in mice (Створена сторінка: A single of us predicted previously that the cytoplasmic end of CHL1 protein may well interact with the cytoskeleton and may well induce/regulate filopodia form...) (поточна)
- 09:28, 29 грудня 2017 (різн. • історія) . . (+6746) . . Н Our findings propose that the suppression of phosphorylation might be the key contributor to the improved (Створена сторінка: One of us predicted previously that the cytoplasmic end of CHL1 protein may interact with the cytoskeleton and may induce/control filopodia formation driving tu...) (поточна)
- 09:04, 28 грудня 2017 (різн. • історія) . . (+6763) . . Н Our findings suggest that the suppression of phosphorylation might be the main contributor to the elevated (Створена сторінка: A single of us predicted earlier that the cytoplasmic stop of CHL1 protein may well interact with the cytoskeleton and may induce/regulate filopodia formation d...) (поточна)
- 08:52, 28 грудня 2017 (різн. • історія) . . (+4800) . . Н Dealt with with enzastaurin to enzastaurin and was connected with similar alterations in the expression of p27Kip1 (Створена сторінка: A wonderful amount of in vitro experiments showed that ROS damages DNA, which seems to represent the key target involved in mutagenesis, carcinogenesis and agin...) (поточна)
- 11:03, 26 грудня 2017 (різн. • історія) . . (+6756) . . Н In summary our multi-disciplinary research exhibits that conveniently binds to high ligand performance and dampens (Створена сторінка: One of us predicted earlier that the cytoplasmic finish of CHL1 protein may well interact with the cytoskeleton and might induce/regulate filopodia development...) (поточна)
- 11:44, 25 грудня 2017 (різн. • історія) . . (+6634) . . Н With improved potency and a lot more favourable pharmacokinetic qualities might also be lively in opposition to (with improved potency and a lot more favourable pharmacokinetic qualities might also be lively in opposition to) (поточна)
- 11:22, 22 грудня 2017 (різн. • історія) . . (+6751) . . Н Equally are based mostly on the pterin substrate a single showcasing gem-dimethyl substitution at the position on the pyrimidine ring (Створена сторінка: One of us predicted beforehand that the cytoplasmic stop of CHL1 protein may well interact with the cytoskeleton and might induce/control filopodia development...) (поточна)
- 07:33, 21 грудня 2017 (різн. • історія) . . (+6240) . . Н Assist to seal the substrate and cofactor binding sites for the chemical transfer of a pyrophosphate from ATP to HMDP (Створена сторінка: In addition, by studying the binding to Diva of Harakiri constructs of different duration we determine the critical location for binding in Harakiri and observe...) (поточна)
- 11:11, 19 грудня 2017 (різн. • історія) . . (+6783) . . Н The relevance of this amino acid residue was presently postulated proposed to focus on it in the inhibitor style method (Створена сторінка: 1 of us predicted earlier that the cytoplasmic conclude of CHL1 protein may interact with the cytoskeleton and may well induce/regulate filopodia development dr...) (поточна)
- 07:20, 18 грудня 2017 (різн. • історія) . . (+6598) . . Н In the 17b-HSD1 assay NADH rather than NADPH is used as cosubstrate. Substrate concentrations are adjusted to the corresponding (Створена сторінка: The protein transduction area transports the fused proteins into cells and permits them to unfold through the entire body by passive diffusion. In the current e...) (поточна)
- 07:07, 18 грудня 2017 (різн. • історія) . . (+6238) . . Н In get to assess the protein-ligand interactions the ligands of the distinct X-ray constructions (Створена сторінка: In addition, by finding out the binding to Diva of Harakiri constructs of various size we discover the [http://www.abmole.com/products/doxorubicin.html Adriamyc...) (поточна)
- 10:55, 13 грудня 2017 (різн. • історія) . . (+5836) . . Н These preclinical findings could have therapeutic implications also thinking about the use of nontoxic doses of PTX (Створена сторінка: HMGA2 is of distinct interest in ESFT due to the fact its overexpression is related with each benign and malignant mesenchymal tumors and simply because it has...) (поточна)
- 10:42, 13 грудня 2017 (різн. • історія) . . (+5935) . . Н Position of Hsp90 which as is a protein substrate for the cytoplasmic HDAC6 isoenzyme may possibly be concerned in p53 stabilization (Створена сторінка: To overcome this dilemma, a packaging/helper plasmid that contains all AAV and Adenovirus functions necessary for amplification and packaging of AAV vector cons...) (поточна)
- 11:02, 12 грудня 2017 (різн. • історія) . . (+5881) . . Н These preclinical conclusions might have therapeutic implications also contemplating the use of nontoxic doses of PTX (Створена сторінка: HMGA2 is of distinct interest in ESFT since its overexpression is connected with equally benign and malignant mesenchymal tumors and due to the fact it has been...) (поточна)
- 10:48, 12 грудня 2017 (різн. • історія) . . (+6190) . . Н Regression in all treated animals with out evidence of illness at the stop of the experiment with antimicrotubule brokers (Створена сторінка: A mounting human body of evidence indicates that malignant cells screen global miRNA silencing. Recent experimental evidence suggests DICER gene deletion in mou...) (поточна)
(найновіші • найдавніші) Переглянути (новіших 50 • старіших 50) (20 • 50 • 100 • 250 • 500).
