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7% in checklist write-in responses). Therefore, we added the general FACIT item ��I am bothered by side effects of treatment�� to the NFBSI-16 with the aim of applicability across patient populations receiving a variety of treatments for breast cancer. After consulting oncology clinician ratings from the development of the FBSI [34], we also included three items representing symptoms/concerns not present in patients' top concerns: shortness of breath (chosen for priority clinical monitoring), difficulty meeting families' needs, and satisfaction with quality of life (as measures of functioning in social roles and general HRQoL). After approximately 30% of interviews and 50% of Quetiapine checklists were completed, we conducted an interim analysis in the larger study to determine what additional patient-generated symptoms/concerns should be included in the physician survey [36]. Three symptoms in the NFBSI-16 www.selleckchem.com/products/Perifosine.html were classified by 100% of physicians as predominantly or exclusively treatment related: nausea, mouth sores, and hair loss. These items and the new ��bothered by side effects of treatment�� item comprise the TSE subscale (Table 4). We placed the remaining items into either the DRS subscale or the F/WB subscale on the basis of expert consensus. The NFBSI-16 presents items within subscales, first the DRS and then the TSE and F/WB. The NFBSI-16, like the FBSI and FACT-B, uses a response scale of 0?(��not at all) to 4?(��very much) and reverse scoring for negative items such that a higher score indicates lower symptomatology and better HRQoL. Patients' mean scores on FACT-B and NFBSI-16 are presented in Table 5. The subset of 13 NFBSI-16?(6 PWB, 4 FWB, 1 EWB, and 2 BCS) items administered as part of FACT-B demonstrated good internal consistency reliability (�� = 0.87). The NFBSI-16 items Selleck FG 4592 were highly correlated with FACT-B, FACT-G, and the PWB, FWB, and TOI subscales (range rs = 0.88�C0.96; P