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Overall, EAI and CAS strains caused more extrapulmonary TB (total P/E ratio 0.5 and 0.6, respectively), but this was nearly solely traceable to the high proportion of African and Asian-born patients with extrapulmonary manifestations (EAI:P/E ratio 0.4 for Africa and Asia; CAS:P/E ratio 0.3 for Africa). In contrast, the predominance of lung TB without associated selleck products extrapulmonary manifestations was highest for the Beijing (W) genotype (total P/E ratio 8.0; nearly solely isolated in Asia-born patients with a P/E ratio 7.0), followed by the T-family (total P/E ratio 2.2, mainly isolated from patients born in Sweden (35% with P/E ratio 2.1), Europe (39%, P/E ratio 4.8) and Africa (30%, P/E 1.4)) and the Haarlem lineage (total P/E ratio 1.6; mainly found among Sweden-born patients with a P/E ratio of 4.3). The isolates were divided into the two principle genetic groups Phosphoprotein phosphatase (PGG). The ancestral or evolutionary older one, PGG1, contained for example Beijing (W), EIA and CAS, and the more modern one, PGG2/3, contained for example T, H and LAM [8,10�C13]. A predominance of the more modern PGG2/3 strains (237/349 or 67.9%) as compared with older PGG1 strains (112/349 or 32.1%) was found. The P/E ratio was 0.9 for PGG1 and 1.8 for PGG2/3 strains, suggesting that irrespective of their specific genotypic lineage attribution, taken cumulatively, all PGG1 strains resulted in a higher proportion of extra?pulmonary disease than PGG2/3 strains (p 0.003, Table?3), which more often caused lung TB. The relation between PGG-based classification and the geographical origin of the patients showed that PGG1 strains were more commonly check details found among the foreign-born patients (101/260, 38.9%) than among the Swedish-born patients (11/89, 12.4%), and this difference was statistically significant (p?