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We included standard laboratory tests. Therapy-related adverse events were defined according to the guidelines of the Society of Interventional Radiology (SIR) [11]. Liver toxicity after CT/MRI-guided HDR brachytherapy was assessed according to the definition of radiation-induced liver disease (RILD), characterized by the occurrence of ascites accompanied by elevated alkaline phosphatase levels or by a serum bilirubin level of �� 3 mg/dl, and ascites 1-2 months after HDR brachytherapy with an absence Liothyronine Sodium of tumor progression or bile duct obstruction [12]. There was no need for lung tests in the follow up period because no clinical symptoms were shown. Definitions of remission criteria and local control rates Local tumor control after CT or MRT-guided brachytherapy was defined according to RECIST 1.1 response criteria and classified either as stable disease (SD), partial (PR), or complete remission (CR) of the treated lesion. Any increase > 20% in diameter of a singular lesion was interpreted as progressive disease (PD). However, restrictions apply for lung and liver follow up. Since in both, lung and liver tissue adjacent to the target volume, focal radiation pneumonitis or radiation Crenolanib datasheet hepatitis may mimic tumor growth. For liver tumors, we therefore limited tumor measurements to hepatobiliary phase imaging > 20 min. post i.v. application of gadoxetic acid (Primovist?). For lung tumors, we measured tumor response not in comparison to the baseline, but to the first follow up examination in order to compensate buy Lapatinib for lung tissue alterations adjacent to the clinical target volume. Statistical methods All results were analyzed in a non-randomized and retrospective approach. To evaluate the local tumor control, the overall survival and the progression free survival statistical analysis was performed employing the Kaplan-Meier method with SPSS version 19 (SPSS, version 19.0; SPSS, Chicago, Illinois). The secondary endpoint safety was evaluated descriptively. Results Treatment characteristics The median diameter of the metastases was 1.5 cm (range: 0.7-10 cm). There were 5 lesions with a maximum tumor diameter between 5 and 10 cm, which were treated with 5 or 6 catheters. Metastases with a maximum tumor diameter of 2 to 5 cm received 1 or 2 catheters depending on the geometrical position of the first catheter implanted, or depending on specifics of adjacent critical organs. Patients with tumor