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In all tested subjects, 20 potential pairs were collected, and the mean consecutive difference (MCD), or jitter value was subsequently calculated for each pair. MCD is the mean of the differences between the intervals between consecutive potential pairs, calculated using dedicated software, and is a standard parameter for the assessment of neuromuscular transmission, reflecting the safety factor of the neuromuscular junction [21]?and?[22]. Filters were set between 500?Hz (high pass filter) and 30?kHz (low pass filter). Sweep velocity was set at 1?ms/division. At least 20 jitter recordings from the frontal muscle were made during voluntary activation in each subject. The results were compared with age-specific normal values for the frontal muscle and considered abnormal when the mean MCD value exceeded the mean normal value, or more than two pairs had an MCD value above the upper limit Tryptophan synthase with or without ZD1839 blocking [24]. The SFEMG was performed 1�C5 days after the TGA incident. Statistical analysis of the data was performed using Statistica 10 software. The chi-square test, Student's t test and multiple comparison test were used to evaluate differences between patients. Statistical significance was set at p?selleck chemicals given age group (Table 2). We analyzed the relationship between the mean MCD value, duration of TGA, and patient age. No significant correlation was found for multiple comparisons (p?=?0.96). No significant correlations were also found between the mean MCD value and patient age (p?=?0.81; the power of the test is 0.06) and between the MCD value and duration of TGA symptoms (p?=?0.87; the power of the test is 0.05). In both cases, the tests were statistically underpowered due to a small patient sample. Our study did not reveal significant NMT dysfunction in TGA patients, as abnormal jitter in the frontal muscle was found only in 1 of 15 patients (6.6%) with TGA. In the study by Ertas et al., abnormal SFEMG findings were noted in 3 of 6 patients with TGA (50%). The mean jitter value in the extensor digitorum communis muscle in TGA patients (35?��?33?��s) was significantly higher than in the control subjects (25.2?��?15?��s) (p?=?0.006, unpaired Student's t test) [19]. In contrast to the study by Ertas et al., we selected the frontal muscle and we used age-specific normal ranges for SFEMG in this muscle, what was not the case in the previous study, because it is well known that reinnervation due to aging may influence the jitter values.