A Decent Solid Double Take On Nutlin-3

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""The authors regret that some errors were made in the Results section, Figure?2 and the legend to Figure?2. Please see the corrected text and figures below. The authors would like to apologise for any inconvenience caused. Results, Outcome, last paragraph, page 114: Kaplan�CMeier survival analysis was used to display survival curves for the factors that affected healing according to regression analysis shown in Table?2. Rest pain (p?=?0.002), maximal extent of tissue destruction (p?Thymidine kinase pressure or ischemic heart disease, showed significant relation to healing over time. Figure options Download full-size image Download high-quality image (187 K) Download as PowerPoint slide Figure options Download full-size image Download high-quality image (229 K) Download as PowerPoint slide Legend to Figure?2. Healing probability (patients' survival free from major amputation) in relation to: 2a �C rest pain, and 2b �C maximal Wagner grade reached during study period. In tables: number of patients at risk. ""What this paper adds This is the largest meta-analysis to date to evaluate the efficacy of exercise programmes in patients with intermittent claudication. A supervised exercise find more therapy regimen is superior to other conservative treatment modalities. A dose�Cresponse trend is found between the intensity of support and improvement in walking capacity in this patient population. In 2010, 202 million people worldwide were coping with peripheral arterial occlusive disease (PAOD).1 During the preceding decade, the number of affected individuals increased by 13.1% and 28.7% in high- and low�Cmiddle-income countries, respectively.1 These huge numbers illustrate that PAOD has become a global health problem affecting vast numbers of individuals. Some 50�C80% of patients with PAOD are symptomatic and suffer from intermittent claudication (IC), the mildest manifestation of in PAOD.2 To protect patients from cardiovascular events and related morbidity and mortality, international guidelines indicate that the treatment of IC should consist of cardiovascular risk management. buy Nutlin-3 Moreover, supervised exercise therapy (SET) is advised to reduce symptoms and restore physical function.2?and?3 However, widespread implementation of SET is restricted by the combination of an insufficient number of available facilities and issues of reimbursement, awareness, and motivation.2, 4, 5?and?6 To overcome some of these problems in the Netherlands, a community-based network for SET was implemented.5 Community-based SET solves the problem of transportation time and costs for individual patients, as well as the restricted capacity of hospital-based SET.