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NIRS-derived autoregulation indices, the cerebral oximetry index (COx) and the hemoglobin volume index Everolimus manufacturer (HVx), were calculated intraoperatively and postoperatively to measure autoregulatory function. The 5-mmHg ranges of optimal mean arterial blood pressure (MAPOPT) with best autoregulation and the lower limit of autoregulation (LLA) were identified. Of seven enrolled patients (aged 2�C16?years), six had intraoperative and postoperative autoregulation monitoring and one had only intraoperative monitoring. Intraoperative MAPOPT was identified in six (86%) of seven patients with median values of 60�C80?mmHg. Intraoperative LLA was identified in three (43%) patients with median values of 55�C65?mmHg. Postoperative MAPOPT was identified in six (100%) of six patients with median values of 70�C90?mmHg. Patients with unilateral disease had higher intraoperative HVx (P?=?0.012) on side vasculopathy. NIRS-derived indices may identify hemodynamic goals that optimize autoregulation in pediatric moyamoya. ""Electronic anesthesia and medical records systems, while uncommon at present, will be widespread in clinical practice within the next 10 years. Anesthesia information management systems hold the promise of enhancing patient care, improving provider workflow, increasing revenue, and improving compliance with clinical guidelines and regulatory requirements. Meaningful input by practicing clinicians during the design and implementation of these electronic systems is CDK inhibitor essential to their successful deployment. ""The aim was to investigate whether cerebral transcutaneous near-infrared Cilengitide spectroscopy (NIRS) or two-site NIRS is a suitable monitoring tool to detect or confirm a cerebral circulatory arrest in pediatric intensive care unit (PICU) patients. Prospective single-center pediatric observational study. Simultaneous NIRS measurements over forehead (cNIRS, crS02) and kidney (rNIRS, rrSO2), at the same time, the cardiac output were determined by transthoracic echocardiography. Area under the curve (AUC) in the receiver-operating curve (ROC) was analyzed for NIRS regarding cerebral circulatory arrest. There were two groups of patients (weight 2.1�C73?kg): Group A: patients with intact cerebral perfusion (n?=?36). Group B: patients with cerebral circulatory arrest (n?=?8) proven by Doppler ultrasound scan or perfusion scintigraphy. There was no difference in cardiac output between the groups. PICU mortality for Group A was 3/36 (8.3%), for Group B 8/8, (100%). Mean cNIRS values were significantly higher with 68.92 (sem?=?2.54, sd?=?15.25) in Group A compared with 34.63 (sem?=?5.36, sd?=?15.15) in Group B (P?