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?brucei subspecies (Supplementary data 1). Out of 18 positive samples belonging to the T.?brucei clade, two samples, one from a spleen and second one from a lymph node of two post-mortem dissected wild Western chimpanzees originating from Ta? NP, C?te d'Ivoire, fell outside of the T.?brucei clade (Table?2; Fig.?2). While TA 11 is almost identical with an unnamed Trypanosoma sp. (Access. No. ""type"":""entrez-nucleotide"",""attrs"":""text"":""JN673403"",""term_id"":""385045194"",""term_text"":""JN673403""JN673403) Vorinostat in vivo from a wildebeest (Connochaetes) captured in Serengeti NP, Tanzania, TA 12 from an adult female chimpanzee from Ta? NP is strongly affiliated with T. theileri (Fig.?2). Due to the limited information residing in the obtained ITS1 region, multiple attempts to amplify (fragments of) the SSU rRNA gene of the above-described GPX5 pathogens were performed seeking to establish more precisely their species status. Unfortunately, these attempts almost invariably failed. However, in the case of the TA 12 tissue sample, a fragment of the SSU rRNA gene was successfully amplified which allowed us to assign the respective parasite with high confidence to T. theileri. 3.3. Trypanolytic capacity of primate sera Only mandrill and human sera (NHS) efficiently lysed T.?b. brucei, with relative survival 0.101?��?0.005 (mean?��?SD; p??0.05) (Supplementary data 2), while this pathogen also prospered in the other sera. The cultured T.?b. rhodesiense cells were very efficiently lysed by the mandrill SB203580 price serum (0.138?��?0.001; p? p?