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Conclusions:? This is the first detailed description of fragmentation and cellularity of the Rbm in smokers, which were most marked in subjects with COPD. The data are consistent with active EMT in these subjects. ""675" "Background and objective:? Resistin-like molecule-�� (RELM-��) is a necessary and sufficient stimulus for airway remodelling in animal models of tuclazepam asthma, but until recently, its role in human disease had not been investigated. The hypothesis that RELM-�� expression would increase with increasing asthma severity and further increase following acute bronchoconstrictor challenges has been examined. Methods:? Bronchial biopsies from healthy subjects and patients with mild and severe asthma were immunostained for RELM-��, as were airway biopsies obtained in mild asthmatics before and 4?days after repeated inhalation challenges with either allergen, methacholine or methacholine preceded by salbutamol as a control. Bronchial brushings were also evaluated for RELM-�� mRNA. Results:? RELM-�� immunoreactivity, which co-localized to airway epithelial http://www.selleckchem.com/products/Tenofovir.html cells, increased with disease severity; healthy volunteers, median per cent epithelial area 1.98%, mild asthma 3.49% and severe asthma 5.89% (P?XAV939 challenge group. These changes correlated with change in basement membrane thickness (r?=?0.38, P?=?0.02). Epithelial RELM-�� gene expression was not altered in asthma. Conclusions:? RELM-�� may play an important role not only in animal models of airway remodelling, but also in human airway pathology. ""676" "The aim of this prospective study was to determine the number of canals treated in the mesio-buccal roots of the maxillary first and second molars teeth of a Saudi Arabian population during a 1-year period in a postgraduate endodontic program. The attending endodontic faculty member supervising the case verified the number of canals in the teeth clinically and radiographically. In total, 308 maxillary first molars and 162 maxillary second molars, of which 158 (51.3%) and 32 (19.7%) met the criterion of having two canals detected and treated in the mesio-buccal root of the maxillary first and second molars, respectively. It was concluded that the occurrence of mesio-palatal canal in the mesio-buccal root of the maxillary first and second molars of a Saudi Arabian population was high. The fact that almost more than half the mesio-buccal roots of the maxillary first molars bear two canals is enough reason to always assume that two canals exist until careful examination proves otherwise.