An Wacky Tariquidar Conspriracy

The hypoplastic SAHA HDAC marrow which occurs in 2% of pediatric ALL patients may be misdiagnosed as aplastic anemia.[2,3] Some authors had suggested that aplastic anemia in the pediatric age group, which responded to steroids, was in fact a pre-leukemic phase of ALL as in another case report, ALL occurred within 6 months of diagnoses of aplastic anemia in children.[4,5] Studies done have shown leukemia to be the second most common cause of pancytopenia in pediatric patients, marginally behind aplastic anemia.[3] The diagnosis of cases presenting with pancytopenia or leukopenia needs complete evaluation of hemogram, peripheral blood and bone marrow picture, immunophenotyping, and cytogenetics with good expertise, especially when there is even the slightest clinical suspicion of leukemia or in a child with unexplained febrile illness. This is essential as the remission, and cure rate for ALL in pediatric age groups are very good with early detection and treatment. In this study, we describe a group of pediatric patients GSK3B in whom pancytopenia was the initial hematological finding and with various evaluation methods, the diagnosis of ALL had been made. The pancytopenic group of ALL was compared with ALL children without pancytopenia. Analysis of peripheral blood, bone marrow, immunophenotyping, cytogenetics, were made to find out the importance of each parameter and have a global approach for prompt diagnosis. The clinical outcome of these patients has also been assessed. Subjects and Methods This is a cross-sectional comparative study done in the Department of Pathology and Paediatric Hemato Oncology, Sri Ramachandra Medical College and Research Institute, Sri Ramachandra University for a period of 5 years, July 2009 to June 2014. The study group includes all the twenty-two patients in the pediatric age group who presented see more with pancytopenia and were evaluated and diagnosed to have ALL in Sri Ramachandra Medical Centre and Sri Ramachandra Medical College Hospital. The criteria for pancytopenia included three factors namely, Total white blood cell (WBC) count