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BRCA1 mutations are often associated with basal-like breast cancer. MCPH1 immunohistochemistry was performed on 319 breast cancers and correlated with pathology, survival, ER, PR, HER2, EGFR, CK5/6, CK14 and BRCA1 data. After performing continuous data analysis mean microcephalin expression decreased with increasing grade, grades 1 and 2 vs. grade 3 (p?Fulvestrant supplier After dichotomizing the data into low and high microcephalin expression, reduced expression was identified in 29% (93/319) of breast cancers. A weak association with low microcephalin expression was identified with overall survival (OS) p?=?0.1 in the whole patient series. This was increased in ductal carcinomas alone (HR?=?0.6, 95%CI: 0.4�C1, p?=?0.054). Multivariate analysis of ductal carcinomas showed that microcephalin, together with stage, was considered an independent predictor of OS (HR?=?0.5, 95%CI: 0.3�C0.851, p?=?0.01). Microcephalin expression is reduced in 29% of breast cancers, particularly in higher grade tumours and is an independent predictor of OS in ductal carcinomas. Microcephalin may prove to be a useful biomarker Alizarin for the identification of aggressive breast cancers. ""Background: Proliferation rates of tumour cells provide prognostic and therapy predictive information. Mitotic index (MI), S-phase fraction (SPF) and Ki67/MIB-1 are used to assess proliferation. Aim: To compare the proliferation assays and explore their correlation. Patients and methods: MI, SPF and 5-year follow-up data were explored for 670 patients from the hospitals of Kalmar County. MI, Ki67/MIB-1 and 3-year follow-up data for 403 patients from the Sahlgrenska University Hospital were extracted. Results: MI and Ki67 were both significantly correlated to early recurrence, p?SB203580 ic50 distant recurrences were distributed in the MI group 1�C3, group 2�C11 and group 3�C25 recurrences. Two pts with Ki67