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In this study, we detected DTMUV replication in the parenchymatous organs of infected ducks in the first 5 days after infection. As shown in Figure ?Figure1,1, the viral titers could be detected in all the tissues tested at 1 dpi and the highest titer was observed in the spleen. In the same period, DTMUV replicated rapidly in the brain, to a high titer. The viral titers in all tissues peaked at 3 dpi, except in the spleen and pancreas. The viral titer in the heart reached 106.7 copies, and those in the spleen, lung and kidney were basically identical. The viral titers in most of the tested tissues began to decline at 5 dpi, but were still highest in the heart. The viral titer in the spleen decreased dramatically at 5 dpi compared with that at 3 dpi, whereas the viral titer in the brain reached 103.8 copies. No virus was detected in the control group. In summary, find protocol DTMUV replicated quickly in many organs, leading to systemic impairment. FIGURE 1 Viral titers in DTMUV-infected ducks at 1, 2, and 3 dpi. Data are expressed as means �� standard deviations (n = 3), and each sample was analyzed in triplicate. Expression of PRR mRNAs in DTMUV-infected Ducks We detected the expression of PRRs (Rig-1, Mda5, and Tlr3) in the brains and spleens of ducks infected with DTMUV during the early post infection period. In the brain, the expression of Rig-1 and Mda5 was upregulated during the first 3 days of infection, and Non-specific serine/threonine protein kinase peaked at 2 dpi and 3 dpi, respectively (4.13-fold and 20.60-fold, respectively, P Tlr3, (D) Il-1��, (E) Il-2, (F) Il-6, (G) Cxcl8, (H) Crizotinib in vivo Mx, (I) Oas, (J) Pkr, (K) Ifn-��, (L) Ifn-��, (M) Ifn-��, (N) Mhc-I, and ... In the spleen, the expression of Rig-1 was upregulated at 1 dpi (2.89-fold) and peaked at 2 dpi (13.62-fold, P