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The frequency of isolation of certain pathogens in chorioamnionitis varies with the study and the type of tissue analysed. The most frequent isolates from placentas of preterm infants were U.?urealyticum (47%) and G.?vaginalis (26%) [3]. Similar microbiological isolates were detected in the amniotic fluid of women with intra-amniotic infection, with the most common organisms detected being U.?urealyticum (47%), Enzalutamide any Gram-negative anaerobe (38.4%), M.?hominis (30.4%), Bacteroides bivius (29.5%) and G.?vaginalis (24.5%) [16]. Viruses may also play a role in chorioamnionitis. Multiple viruses, including cytomegalovirus, adenovirus, enterovirus, respiratory syncytial virus and Epstein�CBarr virus, have been isolated from amniotic fluid [17]. Recently, investigators demonstrated that placental adenovirus infection was strongly associated with histological chorioamnionitis (75% vs. 36%; p?0.026) and PTB (41% vs. 21%; OR?2.6; 95%?CI?1.4�C5.1; p?click here [19�C21]. These infections have been reported in women with in?vitro fertilization pregnancies, in those with retained Histone demethylase intrauterine contraceptive devices, following amniocentesis, and in those with prolonged rupture of membranes [19,22,23]. Only 0.8% of candidal vaginal infections actually ascend into the uterus, and even fewer result in acute chorioamnionitis [20]. However, the complications of intra-amniotic fungal infection can be severe, with a 75% risk of prematurity being associated with candidal funisitis [20]. Also, there are increased risks of mortality in immature/low-birthweight (