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Mean��s.e.m. except for data measured in years, presented as mean (range). All pati ents were middle aged, although men with T2D were slightly older than male controls (P=0.009; Table 2). All groups were matched for BMI; however, the T2D group had higher waist circumference compared Gefitinib with the controls (P=0.022). Among the healthy women, one still had regular menstruation, and one less regularly than previously. The remaining women were post-menopausal, based on patient history. Smoking status, menstruation, and treatment with hormone replacement therapy (n=2 healthy women for all) did not affect the outcome of the analyses. Effect of ACTH stimulation compared with NaCl After both ACTH and NaCl injection, glucose levels were unaffected, whereas serum insulin levels decreased (0 vs 90-min measurements; P=0.033 for ACTH, P=0.044 for NaCl in T2D patients, PDasatinib chemical structure vs 90?min). For healthy subjects, cortisol decreased from 394��23?nmol/l to 244��15?nmol/l after 90?min; POxygenase Serum cortisol levels after administration of dexamethasone The T2D and healthy groups did not differ in fasting cortisol levels after administration of dexamethasone (Table 4). Cortisol levels decreased in all four subgroups after administration of dexamethasone (Table 3). There were no differences in the magnitude of the decrease between the T2D and healthy groups, or by gender. However, those in the T2D group on metformin and SU/repa, compared with those without, had higher serum cortisol levels after administration of dexamethasone (P=0.041).