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Moreover, various opinions have been proposed regarding whether the radiation field should be limited to the region of the primary tumor or extended to the mediastinal lymph node area [4,5]. A Surveillance, Epidemiology and End Results (SEER) database analysis reported that postoperative radiotherapy was efficacious for patients with stage N2 cancer but lowers the survival rate of patients with stage N0 and N1 cancer [11,12]. However, one of the critical limitations of the previous study, due to its retrospective and unmatched design, was that the patients who underwent Capmatinib clinical trial postoperative radiotherapy had more risk factors for recurrence [13,14]. Additionally, it has been Oxygenase pointed out that some patients might have been subjected to radiotherapy with an inappropriate dose or field [11,15]. Here, we evaluated the prognostic significance of T3 subtypes and the role of postoperative radiation therapy in resected stage IIB T3N0M0 NSCLC patients. The study aimed to evaluate the prognostic factors for patients who underwent resection for stage IIB T3N0M0 NSCLC. First, the prognosis of patients was evaluated according to T3 subtype. In addition, we focused on evaluating the efficacy of adjuvant radiotherapy. Using subgroup analyses, we tried to identify a subgroup of patients who might benefit from adjuvant radiotherapy. Materials and Methods 1. Patients In the present study, we conducted a multi-institutional retrospective analysis of 102 patients with postoperative stage T3N0 NSCLC at Wonkwang University Hospital, Wonju IOX1 mouse Severance Christian Hospital, Gangnam Severance Hospital, and Shinchon Severance Hospital. The patients had undergone resection from January 1990 until October 2009 and were selected in accordance with the 7th edition AJCC stage T3N0. Before undergoing the operation, each patient underwent staging workups such as chest computed tomography (CT) and whole-body bone scans. Because the descriptions of T3 tumor extent vary, we categorized the patients into 6 subgroups for T3 tumors: parietal pleura chest wall invasion, mediastinal pleural invasion, diaphragm invasion, separated tumor nodules in the same lobe, endobronchial tumor located