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Lastly, mounting evidence suggests that palliative ERCP-directed PDT, and probably ERCP-directed RFA as well, can offer a survival advantage to patients with this difficult-to-treat malignancy. Footnotes Conflict-of-interest: The authors have no conflicts of interest, financial or otherwise, to report with respect to this manuscript.Dr. Wang discloses that he has received research support from Cefaloridine Cook Medical on the topic of metal biliary stents. Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, Carfilzomib and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ Peer-review started: September 11, 2014 First decision: December 17, 2014 Article in press: February 11, 2015 P- Reviewer: Ramia J, Schmeding M S- Editor: Gong XM L- Editor: A E- Editor: Wu HL""AIM: To examine the discrepancy, if any, between the endoscopist��s estimate and pathologist��s measurement of colonic polyp size. METHODS: We retrospectively studied 88 patients who underwent colonoscopy with a clear unequivocal documentation of polyp size by both endoscopist and pathologist. Endoscopist measurements were based on the visual VX-809 molecular weight estimate of polyp size seen on high definition screens. The measurement was done by our pathologists after formalin fixation. We compared the endoscopist estimate of the polyp size to the pathologist measurement in order to explore the discordance between the two readings. Data regarding demographics and method of polypectomy (snare polypectomy vs excisional biopsy) was collected, as well. Statistical analysis software (SAS) was used to analyze the data. RESULTS: Our cohort included 88 patients from which 111 polyps were removed. Fifty-two (46.8%) of the 111 polyps were excised using biopsy forceps and fifty-nine (53.2%) were removed by snare. In the biopsy forceps group, the mean polyp size documented by the pathologist was 0.38 �� 0.19 cm and the mean polyp size documented by the endoscopist was 0.54 �� 0.16 cm. The mean difference was 0.16 cm (P