Cell Cycle Process

The UVdamaged DNA binding protein mediates effective Cell Cycle Quiz Pdf targeting of the nucleotide 12. Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex. Cell 135: 12131223. Groisman R, Polanowska J, Kuraoka I, Sawada J, Saijo M, et al. The ubiquitin ligase activity within the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA harm. Cell 113: 357367. Sugasawa K, Okuda Y, Saijo M, Nishi R, Matsuda N, et al. UV-induced ubiquitylaysis of crucial elements of known DDB2 protein sub-complexes. DDB1 and Cullin4A in the ubiquitin ligase sub-complex too as CSN5 on the COP9 signalosome subcomplex are detected as well as FLAG-DDB2. Acknowledgments We thank members from the Iglehart laboratory, and Dr. Sylvie Vincent for helpful discussions. Author Contributions Conceived and created the experiments: MD JDI JBL. Performed the experiments: MD ASC JG DJE MRS GLF. Analyzed the information: MD JBL ASC JG DS. Contributed reagents/materials/analysis tools: SI. Wrote the paper: MD JDI JBL DEF SI DS. References 1. Jackson SP, Bartek J The DNA-damage response in human biology and disease. Nature 461: 10711078. 2. Keeney S, Chang GJ, Linn S Characterization of a human DNA harm binding protein implicated in xeroderma pigmentosum E. J Biol Chem 268: 2129321300. 3. Takao M, Abramic M, Moos M Jr, Otrin VR, Wootton JC, et al. A 127 kDa element of a UV-damaged DNA-binding complex, which is defective in some xeroderma pigmentosum group E individuals, is homologous to a slime mold protein. Nucleic Acids Res 21: 41114118. 4. Vermeulen W Dynamics of mammalian NER proteins. DNA Repair 10: 760771. 5. Curtin NJ DNA repair dysregulation from cancer driver to therapeutic target. Nat Rev Cancer 12: 801817. 6. Ravanat JL, Douki T, Cadet J Direct and indirect effects of UV radiation on DNA and its components. J Photochem Photobiol B 63: 88102. 7. Cadet J, Sage E, Douki T Ultraviolet radiation-mediated harm to cellular DNA. Mutat Res 571: 317. 8. Tang JY, Hwang BJ, Ford JM, Hanawalt Pc, Chu G Xeroderma pigmentosum p48 gene enhances international genomic repair and suppresses UVinduced mutagenesis. Mol Cell 5: 737744. 9. Chu G, Chang E Xeroderma pigmentosum group E cells lack a nuclear aspect that binds to damaged DNA. Science 242: 564567. ten. Alekseev S, Kool H, Rebel H, Fousteri M, Moser J, et al. Enhanced DDB2 expression protects mice from carcinogenic effects of chronic UV-B irradiation. Cancer Res 65: 1029810306. 11. Moser J, Volker M, Kool H, Alekseev S, Vrieling H, et al. The UVdamaged DNA binding protein mediates efficient targeting of your nucleotide 12. excision repair complicated to UV-induced photo lesions. DNA Repair 4: 571582. Fujiwara Y, Masutani C, Mizukoshi T, Kondo J, Hanaoka F, et al. Characterization of DNA recognition by the human UV-damaged DNAbinding protein. J Biol Chem 274: 2002720033. Reardon JT, Nichols AF, Keeney S, Smith CA, Taylor JS, et al. Comparative analysis of binding of human broken DNA-binding protein and Escherichia coli damage recognition protein to the key ultraviolet photoproducts: TT, TT, TT, and TT. J Biol Chem 268: 2130121308. Treiber DK, Chen Z, Essigmann JM An ultraviolet light-damaged DNA recognition protein absent in xeroderma pigmentosum group E cells binds selectively to pyrimidine pyrimidone photoproducts. Nucleic Acids Res 20: 58055810.