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Since type of abnormality was significantly associated with targeted/incidental status (P Entinostat order focal or incidental to the biopsy and adequately sampled is not likely to have a more significant upgrade on excision Radiographic and pathologic characteristics of patients with limited volume ALH/LCIS/LN followed clinically Among 104 patients recommended to undergo chemoprevention and surveillance rather than immediate surgical excision the median follow-up time for radiologic surveillance was 3.4 years with a range of 0.44�C8.6 years. Five patients for whom surgical excision was not recommended at the initial management conference subsequently were diagnosed with invasive cancer or DCIS during clinical follow-up. Two patients receiving semiannual mammographic follow-up were diagnosed with malignancy within 2 years; both had DCIS develop Reelin in the ipsilateral breast but in a different quadrant than the initially diagnosed ALH. One patient, with a history of right breast invasive ductal carcinoma and right breast LCIS, received chemoprophylaxis for her newly diagnosed left breast Selleck PLX 4720 LCIS. Five years later she developed a left breast carcinoma in a different quadrant than her biopsy containing LCIS. Only 2 (1.92%) of 104 patients for whom chemoprevention and surveillance was recommended had an upgrade in the same area of the breast where the LN was identified. For these two patients, the time intervals between the disposition conference and cancer diagnosis were 38 and 66 months, respectively (Table ?(Table33). Table 3 Radiology and pathology findings in 5 of 104 patients who developed carcinoma during surveillance and chemoprevention Discussion Our results show that clinical management of LCIS and ALH can be an effective alternative to surgical excision when radiologic and histologic characteristics are well-defined and suggest a low potential for an upgrade at time of excision. We recommend clinical management with serial imaging for patients having limited volume (