Crank That CP-868596 In To A Total Goldmine

The 95th percentile value, and hence the upper limit of normal, was calculated at 13 SGB per 24 hours. We identified 100 patients (54 female) with excessive SGB, giving a prevalence of 3.4% in our referral population. The mean age of these patients was 48 (median 47) and age range was 12 to 84 years. Ninety-five out of 100 patients suffered from typical reflux symptoms (heartburn and regurgitation). Eighty-six Selleck CP-868596 patients reported excessive belching with 50 considering that belching was their predominant symptom. Sixty-five patients reported dysphagia, 16 had non-cardiac chest pain, 51 excessive bloating, and 15 epigastric pain. Twenty-nine of the patients had hiatal hernia which was diagnosed with HRM. The frequency of SGB displayed considerable inter-individual variability. The number of SGB episodes counted within 24 hours ranged between 17 and 510 (median 69, mean 101). The 25th and the 75th percentile were 37 and 124 SGB episodes per 24 hours respectively. Forty-one out of 100 patients with excessive SGB had pathological acid exposure ranging from 4.3% to 54.1%. Compared to the patients with normal acid exposure these GW-572016 patients had a trend towards a higher number of SGB episodes (109.2 �� 93.1 vs 90.1 �� 93.9, P = 0.110), 39 out of 41 had typical reflux symptoms and 37 reported bothersome belching. In the patients with increased SGB and pathological acid exposure, we assessed the acid reflux episodes that occurred immediately after (within 1 second) a SGB (Fig. 1). The median number of these episodes was 12.5 (range 0 to 65) per patient. Acid exposure time due to reflux episodes occurring immediately after SGB corresponded to a mean 27% of the total acid exposure time (median 18%, range 0% to 79% of the 24-hour acid exposure) in these patients.5 Figure 1. Example pH-impedance tracing showing a supragastric belch followed immediately by a gastresophageal reflux event. On HRM 44 patients out of 100 had esophageal PTPRJ hypomotility. Thirty-one of them reported dysphagia. According to the Chicago classification6 18 had frequent failed peristalsis, 16 had weak peristalsis with large defects, 10 weak peristalsis with small defects. Patients with hypomotility had a significantly higher frequency of SGB compared to the group with normal motility (118.3 �� 106.1 vs 80.6 �� 75.7, P = 0.020; Fig. 2 and Fig. 3). This was true even when patients with pathological esophageal acid exposure were excluded from analysis (102.5 �� 105.6 vs 68.7 �� 68.9, P