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11?and?17 The number of measurements meeting the tissue oxygenation warning criterion (PmO2?Temozolomide of PmO2 and CP of the healthy leg and the injured leg were compared using Wilcoxon ranked sums test for paired data. The proportion of measurements meeting prospectively defined warning criteria were calculated and compared for PmO2 and CP or ��P using Wilcoxon ranked sums test for paired data. The experimental arm consisted of 10 patients (7 male, 3 female). Mean age was 40.5 years (range, 25�C83 years). The mechanism of injury was: motor vehicle accident (n?=?3), pedestrian versus automobile (n?=?3), assault (n?=?2) and torsional injury (n?=?2). Probes Vismodegib datasheet were well tolerated. No probe-related complications occurred. None of the 10 patients developed compartment syndrome postoperatively. This assessment was based on a normal sensorimotor exam of the lower extremity, adequate pain control on oral medication and ability to mobilise adequately for discharge from the hospital. These patients were followed postoperatively in the orthopaedic clinic and none had physical exam evidence of a missed compartment syndrome. All patients underwent intramedullary nailing of the tibia under anaesthesia. The average healthy leg mean PmO2 was 30.45?mmHg and average injured leg mean PmO2 was 27.24?mmHg; the difference between the healthy and injured legs was not statistically significant (P?=?0.08). The average healthy leg mean CP (measured in nine patients) was 17.19?mmHg and the average injured leg Moroxydine mean CP was 30.67?mmHg; the difference between the healthy and injured legs was statistically significant (P?=?0.02). The mean duration of CP measurements was 33.35?h, while the mean duration of ��P measurements (n?=?9 eligible) was 27.8?h. Qualitative analysis of postoperative PmO2 data revealed no appreciably reproducible pattern. In 8 of 10 patients, CP appeared to be highest immediately postoperatively and then gradually decreased over time. Statistically significant correlations (P?