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The thickness and fibrosis scores of LF in the LSS group were higher than that in the control group (all P?find more increased the mRNA expression and protein synthesis of types I and III collagen of the LF cells (all P?BML-190 expression levels were elevated 1 week after surgery and peaked at 77 fold at 2 weeks compared to expression at 3 days. A 55% decrease of Mmp13 levels in cartilage was observed 48?h after injection of Mmp13 siRNA (p?=?0.05). DAPT Significant reduction in the histological score at 8 weeks after surgery was observed in the Mmp13 siRNA-treated group compared to the control siRNA group (p?