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The protection of the great apes and their habitat is a pre-condition for such studies. No conflict of interest to be declared. ""Clin Microbiol Infect 2011; 17: 300�C305 Increasing antimicrobial resistance in nontyphoidal Salmonella (NTS) species complicates the use of antibiotics if indicated. We investigated the impact of antimicrobial resistance on clinical outcomes and discussed Temozolomide nmr how to use antibiotics rationally. Hospitalized children in 2005�C2006 with stool cultures positive for NTS were identified. The clinical and microbiological features were retrospectively reviewed. A total of 683 children were included [371 (54.3%) male; 89.5% Veliparib molecular weight reach high tissue concentrations in the intestinal mucosa were administered, such as fluoroquinolone or ceftriaxone. It is concluded that adequate antibiotics may be clinically beneficial to a subset of patients with high CRP and longer duration of fever among children with NTS enteritis. To prevent the induction of antibiotic resistance from this therapy, we suggested a short course (3�C5?days) of intravenous ceftriaxone for such patients, which would lead to a faster clinical recovery. Nontyphoidal Salmonella (NTS) infection is still a DDR1 serious threat to global public health [1�C4]. Most NTS infections result in mild-to-moderate enteritis, although systemic infections, including bacteraemia and meningitis, may occur, especially in infants and immunocompromised hosts [5,6]. Antimicrobial therapy is not recommended for routine treatment of nontyphoidal salmonellosis [7,8]; however, effective antibiotic treatment is essential if NTS infection spreads beyond the intestine or if NTS enteritis occurs in patients with low immunity (e.g. infants younger than 3?months of age and patients with immunosuppressive illnesses) [9]. Antimicrobial therapy may also be considered in severely ill immunocompetent adult patients, such as those with severe diarrhoea (more than nine or 10 stools per day), high fever, or those needing hospital admission [10].