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The top rows in Fig.?3 show the left and right sides of the amygdala, the middle row shows those of the hippocampus, and the bottom row shows those of?the ERC. The Thymidine kinase curves for the amygdala and the hippocampus are highest at around 2?years before clinical onset, while the likelihood for the ERC is largest at around 10?years before onset. The bootstrap-estimated standard deviations of these sample estimates lie between 1 and 3?years as reported in Table?2. Table?2 also provides the p-values associated?with the changepoint model for the ERC, amygdala, and hippocampus. The segment-averaged measures in the right hemisphere show significant differences between the groups as follows: the ERC is significant (p=?0.004) with a changepoint?at around 8.5?years (��2.8). The hippocampus is marginally significantly different (p=?0.024), with a changepoint estimated at 3.6 (��1.4) years prior to symptom onset, and the amygdala is strongly significant (p=?0.0015), with a changepoint at 2.7 (��1.9) years before onset. For the left hemisphere, the significant differences are as follows: (1) the entorhinal cortex demonstrates a significant difference (pselleck compound significance. The volume measures are significant for the amygdala (left: p=?0.003, right: p=?0.006), significant on the left side (p=?0.017) for the hippocampus, and not significant on the right (p=?0.27). Volume is significant for the ERC (left: pfind more in each structure. The evolution starts with a nearly horizontal line, which coincides with the one associated?with controls, then changes to a steeper slope at changepoint. The smoothness of the transition is due to averaging, since changepoints are not identical for each segment. The middle row in Fig.?4, Fig.?5?and?Fig.?6 plots these curves against subject age, while the bottom row provides the same curves shifted by clinical onset age, which enables comparison (the slopes are the same in both cases, even though the unshifted curves appear steeper; this is due to the rescaling of the horizontal axis for shifted curves).