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3D). Despite increased GSSG levels, CDME-loaded cells displayed normal GSH/GSSG redox potential (Fig. 3E). Interestingly, siCTNS-transfected cells showed a moderate, but significant, increase in GSH/GSSG redox potential when compared with MT (?226.82 �� 4.2 versus?243.20 �� 2.46 mV, respectively, P found to be increased by ?30% (P Selleckchem CAL-101 intracellular levels of H2O2, a product of SOD activity, were determined. Intracellular H2O2 levels were significantly increased following incubation of cells in 500 ��m CDME when compared with control cells (2.1 �� 0.4 versus 0.7 �� 0.3 nmol (mg protein)?1, SKAP1 respectively, P or CTNS gene silencing. Exposure of cells to either 200 or 500 ��m CDME markedly increased the DFFH fluorescence by 32 (P 0.01) and 60% (P Saracatinib in cells following CTNS gene inhibition when compared with MT (123.7 �� 8.5 versus 86.0 �� 3.9 U (mg protein)?1, respectively, P