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This instrument has been shown to be valid and reliable when used for psychiatric screening in outpatient settings.[13] Scores for each subscale range from 0 to 21. In the present study, HADS scores were classified Enol according to the criteria outlined by Zigmond and Snaith,[12] where a score of 11 or more indicates a clinically significant case of anxiety or depression (��case��), scores of 8�C10 (inclusive) indicate a possible case of depression or anxiety (��borderline case��) and scores of 7 or lower indicate no evidence of depression or anxiety (��no case��). Participants were excluded from the analysis if HADS scores were not recorded in the registry. Statistical analysis of the data was performed using SPSS software version 19.0 (IBM Corp, Chicago, IL, USA). The prevalence of ��cases��, ��borderline cases�� and ��no cases�� of anxiety and depression was measured using frequencies and percentages. We tested the association among anxiety and depression and demographic data (gender, age, diagnosis, body mass index, use of oxygen and presence of comorbidities), measures of disease severity (FVC, DLCO, TLC, RV, 6MWT baseline SpO2 and 6MWT nadir SpO2) and measures of disease impact (MMRC score) using Pearson's Chi-squared test for categorical variables and one-way anova for continuous variables. Variables with a univariate relationship to anxiety or depression (P?FDA approved Drug Library price correctly classified by the model. The criterion used for model accuracy was that the proportion correctly classified should exceed the proportional-by-chance CDK inhibitor accuracy by 25%. Overall relationships between independent and dependent variables were evaluated using Likelihood Ratio Tests. The relative differences in risk for ��borderline cases�� or ��cases�� compared with the reference category were expressed with odd ratios and 95% confidence intervals. Presence of outliers was evaluated using sensitivity analysis with binomial logistic regression. Results were considered statistically significant when P values were