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29 for the 22-item ZBI) and showed appropriate ICC with items 2, 3, 9, 17, and 22 as the most discriminative ( Table 3). Selleck LGK 974 Fig. 1?and?Fig. 2 show the ICC from the Samejima��s parametric GRM. As seen, most items presented a shape and category threshold compatible with appropriate difficulty and discrimination parameters. The main exception were item 8 (do you feel your relative is dependent on you?) and to a lesser extent items 18 (do you wish you could leave the care of your relative to someone else?) and 19 (do you feel uncertain about what to do about your relative?). The 12-item ZBI CFA results fitted to a unidimensional latent structure (CFI=0.975; RMSEA=0.067; weighted root mean square residual=0.677). Inspection of standardized residuals and modification indexes indicated no localized points of ill fit in the final solution apart from including a correlated measurement error between items 11 and 12 (r=0.51). All freely estimated unstandardized parameters were statistically significant (PAZ191 dementia. The unidimensionality of the 12-item ZBI suggested by Mokken analysis was confirmed by CFA. We interpret this structure as corresponding to the latent construct of subjective burden experienced by the Apoptosis Compound Library caregiver. Table 4 presents a comparative view of the structure of the several ZBI short forms published until now [32], [33], [34]?and?[35]. As seen, our suggested scale is quite close to that proposed by B��dard et al. [32], with both scales sharing eight items over 12. It is interesting to note the high variability of items ascribed to the different short scales. In fact only three items were not presented in any of the reported short forms of the parental ZBI (item 1: asking for more help than needed, item 7: afraid about the future, and item 15: financial problems). Some authors [19] have proposed an extreme 1-item reduction of the 22-item ZBI, suggesting that to obtain an overall summary of burden no more than item 22 is needed. It is true that the ICC for this item behaves quite well (Fig. 2) and also retained a good percentage of the total information and a strong factorial loading on the latent construct (Table 3). However, it is not less true that item 22 acts as an anchor item to summarize the whole ZBI scale once the caregiver has answered all the former items.