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18 English-language articles published in Web of Science, PubMed and Cochrane Library up to June 2012 were searched using the following strategy: (��obesity�� or ��obese�� or ��body mass index��) and (��trauma�� or ��injury��). References cited by chosen articles were checked manually for any other potential studies. Studies chosen for the analysis fulfilled the following inclusion criteria: (1) population: patients older than 13 years with either blunt or penetrating, single or multiple injuries. Vismodegib in vivo (2) Intervention or exposure: different body weight levels based on body mass index (BMI) categorised according to the World Health Organization (WHO) guideline19 (BMI?��?30?kg?m?2 as obese and BMI?Moroxydine Two investigators independently reviewed the title and abstract of all potential articles and selected articles fulfilling Temozolomide mouse our inclusion criteria for full text analysis. Data extracted from these articles included first author's name, publication year, study design, inclusion and exclusion criteria, patients number of each BMI strata and first and secondary outcomes. Disagreements were resolved by either consensus or a third-party decision. Because it was not viable to carry out the RCT to evaluate the effect of obesity on trauma, all studies included in the meta-analysis were observational studies combined by a cohort study and a case�Ccontrol study. To assess the quality of these studies we used a previously designed criteria adapted by Taggart et al.,20 which examined five factors: participant selection, comparability groups, outcomes, size and cohort design. Descriptions for each component of the quality assessment are outlined in Table 1. Studies without score in any category were excluded. All statistical analysis was performed utilising Stata/SE 11.0 (Stata Corporation, College Station, TX, USA). As to studies that did not stratified outcomes based on BMI categories of ��30?kg?m?2 and