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Treatment efficacy of denosumab did not differ with kidney function. Denosumab was not associated with an increase in adverse events among patients with impaired kidney function [7]. THERAPEUTIC EFFICACY Effects on bone turnover markers In a study to evaluate the efficacy and safety of subcutaneously administered denosumab over a period of 12 months in postmenopausal women (n=412) with low bone mineral density (BMD), denosumab groups showed decreases in levels of serum C-telopeptide (CTX), compared with the placebo group (PBLZ945 mouse the first scheduled time point after baseline [8]. The maximum mean percentage reduction in levels of serum CTX was 88% among the denosumab groups compared with 6% in the placebo group. The results of the urinary NTX/creatinine ratio were similar to those for serum CTX. There was a 1 month delay in the decrease in serum bone-specific alkaline phosphatase levels in subjects receiving denosumab (PPFKM year of denosumab treatment remained consistent, compared with the first year of treatment, and statistically greater than the placebo group (P��0.002) [9]. In the Determining Efficacy: Comparison of Initiating Denosumab vs. alEndronate trial (DECIDE; n=1,189), which compared the efficacy and safety of denosumab with oral alendronate 70 mg once weekly in postmenopausal women with low bone mass, serum CTX reduction in denosumab-treated subjects was rapid, with maximal median decreases from baseline observed at month 1 (-89%) and was significantly greater than that observed for alendronate-treated subjects (-61%, PBMS-754807 research buy were greater in the denosumab group than the alendronate group (-89% vs. -66%, P