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A significant difference was a noted in the Pitt bacteraemia score. Patients with SKP BSI had a low Pitt bacteraemia score of 2, compared with patients with ESBLKP or CRKP (scoring 3 and 4, respectively; p?BEZ235 p?http://www.selleckchem.com/products/ve-821.html of patients with K.?pneumoniae BSI. We found that severity of illnesses and carbapenem resistance were strong prognostic factors for mortality. The impact of antibiotic resistance on the outcome for patients with nosocomial infections is controversial. Although it is generally accepted that drug resistance is associated with increased morbidity and mortality [17,19], some studies found no such relationship [20,21]. Underlying co-morbidities, delay in the initiation of appropriate antimicrobial therapy, and the severity of illness of the patients infected by the multidrug-resistant pathogens, may be important confounders [22,23]. Therefore, appropriate adjustment for these confounding factors is essential in studies that determine the impact of antimicrobial resistance. In the present study, we found that carbepenem Parvulin resistance was an independent risk factor for mortality among patients with K.?pneumoniae BSI. Recently, a few studies have demonstrated that carbapenem resistance was associated with increased mortality. Patel et?al. [12] have included in their study various infections, while Schwaber et al. [10] have included patients with clinical isolates that may represent only colonization. In both studies, control patients had a significantly shorter length of hospital stay compared with case patients (a median of 2?days compared with more than 20?days).