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We set a 95% Cell Cycle inhibitor confidence level for the two-tailed hypothesis tests. Table 1 shows the sociodemographic and clinical characteristics of the participants. As regards treatment, 3 of the children had CSII pumps with a rapid-acting insulin analogue, and the remaining children used MDII. Of the latter, 45 received a combination of long-acting insulin analogues (insulin glargine or detemir) and rapid-acting insulin analogues (insulin lispro, aspart or glulisine), and 6 received a combination of neutral protamine Hagedorn (NPH) insulin and rapid-acting insulin analogues (insulin lispro, aspart or glulisine). None of the participants exhibited microvascular complications. A significant reduction in insulin requirement was observed during the camp (0.85?��?0.26?IU/kg at the start of the camp vs 0.69?��?0.24?IU/kg at the end, p?Rolziracetam high risk of hypoglycaemia in 26% of the participants and a moderate risk in 39%. The median urinary excretion rate of 8-iso-PGF2�� measured in 14 children at the end of the camp was 864.39?pg/mg creatinine. We found no statistically Cobimetinib research buy significant differences in markers of glycaemic variability (SD, MAGE, MODD and HBGI), HbA1c, duration of diabetes (4.79?��?3.28 years vs 4.75?��?3.18 years; p?=?0.98), age (11.86?��?1.91 years vs 11.25?��?2.46 years; p?=?0.33) and sex (50% male vs 42.5% male, p?=?0.63) between the children who submitted the 24-hour urine sample and those who did not ( Table 2). LBGI and time in hypoglycaemia were significantly lower in the group of children who did not submit the urine sample ( Table 2). Table 3 shows the positive and statistically significant correlations that were observed between duration of diabetes, HbA1c, mean glycaemia, SD and the HBGI, and MAGE and MODD indices. LBGI correlated positively with MAGE and negatively with mean glycaemia. However, neither age nor urinary excretion rate of 8-iso-PGF2�� correlated with markers of glycaemic variability (Table 3). This study shows considerable glycaemic variability in children and adolescents with T1DM attending a summer camp.